ArticlePlant cell reports2014
High contents of very long-chain polyunsaturated fatty acids in different moss species.
Article in Plant cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- A Review of Bryophytes: Enzymatic and Non-Enzymatic Antioxidants as a Key for Their Pharmacological Potential and Green-Biotechnological Application.Antioxidants (Basel, Switzerland) · 2025Review
- Phylogenetic Aspects of Higher Plant Lipid Fatty Acid Profile.International journal of molecular sciences · 2025Review
- Comparative Metabolite Profiling of Antarctic and Korean Mosses: Insights into Adaptation Mechanisms of Antarctic Moss Species.Plants (Basel, Switzerland) · 2025Article
- Recent advances and future directions on GLA-producing organisms.Frontiers in bioengineering and biotechnology · 2025Review
- Transcriptome analysis of the common mossAoB PLANTS · 2024Article
- Dynamic Membrane Lipid Changes inBiology · 2024Article
- Article
- Lipid Metabolism and Improvement in Oilseed Crops: Recent Advances in Multi-Omics Studies.Metabolites · 2023Review
- Lipidomic analysis of moss speciesPlant-environment interactions (Hoboken, N.J.) · 2022Article
- Chemotaxonomic and evolutionary perspectives of Bryophyta based on multivariate analysis of fatty acid fingerprints of Eastern Himalayan mosses.Protoplasma · 2022Article
- Article
- Effects of extraction parameters on lipid profiling of mosses using UPLC-ESI-QTOF-MS and multivariate data analysis.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Convergence of sphingolipid desaturation across over 500 million years of plant evolution.Nature plants · 2021Article
- Arachidonic acid inhibits the production of angiotensin-converting enzyme in human primary adipocytes via a NF-κB-dependent pathway.Annals of translational medicine · 2020Article
- Comprehensive analysis of the Ppatg3 mutant reveals that autophagy plays important roles in gametophore senescence in Physcomitrella patens.BMC plant biology · 2020Article
- Lipid Metabolism in Plants.Plants (Basel, Switzerland) · 2020Article
- Valuable Fatty Acids in Bryophytes-Production, Biosynthesis, Analysis and Applications.Plants (Basel, Switzerland) · 2019Review
- Genetically Engineered Oil Seed Crops and Novel Terrestrial Nutrients: Ethical Considerations.Science and engineering ethics · 2019Article
- Functional Characterization ofPlants (Basel, Switzerland) · 2019Article
- Membrane Lipids, Waxes and Oxylipins in the Moss Model Organism Physcomitrella patens.Plant & cell physiology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acids (PUFAs) are important cellular compounds with manifold biological functions. Many PUFAs are essential for the human diet and beneficial for human health. In this study, we report on the high amounts of very long-chain (vl) PUFAs (≥C₂₀) such as arachidonic acid (AA) in seven moss species. These species were established in axenic in vitro culture, as a prerequisite for comparative metabolic studies under highly standardized laboratory conditions. In the model organism Physcomitrella patens, tissue-specific differences in the fatty acid compositions between the filamentous protonema and the leafy gametophores were observed. These metabolic differences correspond with differential gene expression of fatty acid desaturase (FADS)-encoding genes in both developmental stages, as determined via microarray analyses. Depending on the developmental stage and the species, AA amounts for 6-31 %, respectively, of the total fatty acids. Subcellular localization of the corresponding FADS revealed the endoplasmic reticulum as the cellular compartment for AA synthesis. Our results show that vlPUFAs are highly abundant metabolites in mosses. Standardized cultivation techniques using photobioreactors along with the availability of the P. patens genome sequence and the high rate of homologous recombination are the basis for targeted metabolic engineering in moss. The potential of producing vlPUFAs of interest from mosses will be highlighted as a promising area in plant biotechnology.
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