ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014
Quantitative MRI in the evaluation of articular cartilage health: reproducibility and variability with a focus on T2 mapping.
Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Bone marrow edema-like signal after cartilage repair does not affect outcomes in a five-year follow-up.European radiology · 2025Article
- Same-model and cross-model variability in knee cartilage thickness measurements using 3D MRI systems.PloS one · 2025Article
- DeepEMC-TMagnetic resonance in medicine · 2024Article
- Correlation between the quality of cartilage repair tissue and patellofemoral osteoarthritis after matrix-induced autologous chondrocyte implantation at three-year follow-up: a cross-sectional study.International orthopaedics · 2023Article
- Ultrasonographic echo intensity in the medial femoral cartilage is enhanced prior to cartilage thinning in women with early mild knee osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- MAVRIC based T2 mapping assessment of infrapatellar fat pad scarring in patients with total knee arthroplasty.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Quantitative T2 mapping monitoring the maturation of engineered elastic cartilage in a rabbit model.BMC medical imaging · 2023Article
- T2 mapping for knee cartilage degeneration in young patients with mild symptoms.BMC medical imaging · 2022Article
- Correlation of Postoperative Imaging With MRI and Clinical Outcome After Cartilage Repair of the Ankle: A Systematic Review and Meta-analysis.Foot & ankle orthopaedics · 2022Article
- TSkeletal radiology · 2022Article
- Quantitative MRI evaluation of articular cartilage in patients with meniscus tear.Frontiers in endocrinology · 2022Article
- The Response of Hip Joint Cartilage to Exercise in Children: An MRI Study Using T2-Mapping.Cartilage · 2021Observational
- Reproducibility of an Automated Quantitative MRI Assessment of Low-Grade Knee Articular Cartilage Lesions.Cartilage · 2021Article
- Quantitative MRI T2 Mapping is Able to Assess Tissue Quality After Reparative and Regenerative Treatments of Osteochondral Lesions of the Talus.Journal of magnetic resonance imaging : JMRI · 2021Observational
- Article
- Promising radiological outcome after repair of acetabular chondral defects by microfracture augmented with chitosan-based scaffold: mid-term T2 mapping evaluation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Quantitative ultrashort echo time magnetization transfer (UTE-MT) for diagnosis of early cartilage degeneration: comparison with UTE-T2* and T2 mapping.Quantitative imaging in medicine and surgery · 2020Article
- The Effects of Well-Rounded Exercise Program on Systemic Biomarkers Related to Cartilage Metabolism.Cartilage · 2019Article
- T2 mapping of cartilage and menisci at 3T in healthy subjects with knee malalignment: initial experience.Skeletal radiology · 2019Article
- Detection of Early-Stage Degeneration in Human Articular Cartilage by Multiparametric MR Imaging Mapping of Tissue Functionality.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly diagnosis of cartilage degeneration and longitudinal tracking of cartilage health including repair following surgical intervention would benefit from the ability to detect and monitor changes of the articular cartilage non-invasively and before gross morphological alterations appear.
methodsQuantitative MR imaging has shown promising results with various imaging biomarkers such as T2 mapping, T1 rho and dGEMRIC demonstrating sensitivity in the detection of biochemical alterations within tissues of interest. However, acquiring accurate and clinically valuable quantitative data has proven challenging, and the reproducibility of the quantitative mapping technique and its values are essential. Although T2 mapping has been the focus in this discussion, all quantitative mapping techniques are subject to the same issues including variability in the imaging protocol, unloading and exercise, analysis, scanner and coil, calculation methods, and segmentation and registration concerns.
resultsThe causes for variability between time points longitudinally in a patient, among patients, and among centres need to be understood further and the issues addressed.
conclusionsThe potential clinical applications of quantitative mapping are vast, but, before the clinical community can take full advantage of this tool, it must be automated, standardized, validated, and have proven reproducibility prior to its implementation into the standard clinical care routine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.