Evidence map›Paper›PMID 24170170›Full record

ArticleThe American journal of psychiatry2014

Effect of knowledge of APOE genotype on subjective and objective memory performance in healthy older adults.

Tara T Lineweaver, Mark W Bondi, Douglas Galasko, David P Salmon

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04471779 (The IDEAL Study), which is not on this map. Cited by 75 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04471779 nacompletednot on this mapstarted 2021, after this paper: background citation

The IDEAL Study: Information About Alzheimer's Disease for Latinos in New York City

TypeinterventionalSponsorColumbia UniversityRan2021 to 2025Enrolled374ConditionsAlzheimer DiseaseArmsDisclosure of APOE genotype
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Trial
  9. Longitudinal Trajectories of the Cognitive Function Index in the A4 Study.The journal of prevention of Alzheimer's disease · 2024
    Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Apoe genotype knowledge and its impact on cognitive beliefs and performance.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tara T Lineweaver
Mark W Bondi
Douglas Galasko
David P Salmon

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
Cognitive Abilities of At-Risk Elderly for DementiaR01AG012674 · NIA · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI BONDI, MARK W · 2001 to 2012
$2.7M
Neuroimaging and Risk Factor Correlates in Aging and MCIK24AG026431 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W · 2007 to 2016
$1.7M
NIA NIH HHS K24 AG026431NIA NIH HHS K24-AG 026431NIA NIH HHS P50 AG005131NIA NIH HHS P50-AG 05131NIA NIH HHS R01 AG012674NIA NIH HHS R01-AG 012674
6 · The paper itself

Abstract

objectiveThe knowledge that one carries the apolipoprotein E (APOE) ε4 allele risk factor for Alzheimer's disease was recently found to have little short-term psychological risk. The authors investigated the impact of knowledge of carrying the risk allele on subjective ratings of memory and objective memory test performance of older adults.

methodUsing a nested case-control design, the authors administered objective verbal and visual memory tests and self-rating scales of memory function to 144 cognitively normal older adults (ages 52-89) with known APOE genotype who knew (ε4+, N=25; ε4-, N=49) or did not know (ε4+, N=25; ε4-, N=45) their genotype and genetic risk for Alzheimer's disease prior to neuropsychological evaluation.

resultsSignificant genotype-by-disclosure interaction effects were observed on several memory rating scales and tests of immediate and delayed verbal recall. Older adults who knew their ε4+ genotype judged their memory more harshly and performed worse on an objective verbal memory test than did ε4+ adults who did not know. In contrast, older adults who knew their ε4- genotype judged their memory more positively than did ε4- adults who did not know, but these groups did not differ in objective memory test performance.

conclusionsInforming older adults that they have an APOE genotype associated with an increased risk of Alzheimer's disease can have adverse consequences on their perception of their memory abilities and their performance on objective memory tests. The patient's knowledge of his or her genotype and risk of Alzheimer's disease should be considered when evaluating cognition in the elderly.

Indexed as

MemoryAgedAged, 80 and overAgingAllelesApolipoprotein E4Case-Control StudiesFemaleGenotypeHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedPsychomotor PerformanceSelf ReportApolipoprotein E4

Identifiers

PMID24170170
PMCPMC4037144

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.