Trial reportWorld journal of surgery2014
Electrochemotherapy treatment of locally advanced and metastatic soft tissue sarcomas: results of a non-comparative phase II study.
Trial report in World journal of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- UK guidelines for the management of soft tissue sarcomas.British journal of cancer · 2025Guideline
- Locoregional Treatment of Bone Metastases in a Lung Cancer Patient: A Case Report Using Multiple Techniques: Electrochemotherapy, Cryoablation, and Cementoplasty.Reports (MDPI) · 2026Article
- The Rising Power of Electrochemotherapy in Musculoskeletal Oncology.Current oncology (Toronto, Ont.) · 2026Review
- Custom bipolar electrode for bleomycin-based electrochemotherapy in patient-derived uveal melanomaFrontiers in cell and developmental biology · 2026Article
- Tumor ablation in children.Pediatric radiology · 2025Review
- Electrochemotherapy Intralesional Treatment in a Captive Peregrine Falcon (Animals : an open access journal from MDPI · 2025Article
- A Review on Canine and Human Soft Tissue Sarcomas: New Insights on Prognosis Factors and Treatment Measures.Veterinary sciences · 2024Review
- Article
- Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma.Materials (Basel, Switzerland) · 2021Review
- Article
- Article
- Electrochemotherapy as Promising Treatment Option in Rare Recurrent Cutaneous Neoplasm of the Scalp: Case Report of an Elderly Patient.Case reports in oncological medicine · 2019Article
- Effect of Tissue Inhomogeneity in Soft Tissue Sarcomas: From Real Cases to Numerical and Experimental Models.Technology in cancer research & treatment · 2018Article
- Microscopic histological characteristics of soft tissue sarcomas: analysis of tissue features and electrical resistance.Medical & biological engineering & computing · 2017Article
- Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients.Pharmacogenomics · 2016Review
- Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats.Journal of visualized experiments : JoVE · 2016Article
- Electrical resistance of human soft tissue sarcomas: an ex vivo study on surgical specimens.Medical & biological engineering & computing · 2016Article
- A prototype of a flexible grid electrode to treat widespread superficial tumors by means of Electrochemotherapy.Radiology and oncology · 2016Article
- Recommendations for improving the quality of reporting clinical electrochemotherapy studies based on qualitative systematic review.Radiology and oncology · 2016Review
- UK guidelines for the management of soft tissue sarcomas.Clinical sarcoma research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsOur aim was to evaluate the activity, toxicity, and feasibility of electrochemotherapy (ECT) in patients with soft-tissue sarcomas (STS).
methodsA two-stage phase II trial was conducted between October 2006 and March 2012. Patients (N = 34) with locally advanced or metastatic STS, unsuitable for standard oncological treatments and with maximum 3-cm deep tumors, received an intravenous bolus of bleomycin (15,000 IU/m(2)), followed by tumor electroporation according to the European Standard Operating Procedures of ECT. Outcome measures included local response according to response evaluation criteria in solid tumors (RECIST), toxicity and tumor control. Feasibility measures included the accuracy of electrode placement and the intensity of electric current flowing in tumor tissue.
resultsMedian tumor size was 4.0 cm (range 2-12). Objective response, assessed on 71 target lesions, was 92.2 % (complete 32.3, 95 % CI 28-64). A total of 15 patients received up to four cycles due to incomplete response, but re-treatment did not significantly improve outcome (p = 0.205). After a median follow-up of 19.3 months, 2-year local control rate was 72.5 %. Median time to local failure (N = 11 patients) was 5.1 months. Tumor response (p = 0.041) and control (p = 0.047) correlated with histological grading. Relevant toxicity consisted of G3 skin ulceration and soft tissue necrosis (35 and 23 % of patients, respectively), although this was manageable on an outpatient basis. The accuracy of electrode placement was 47.1 %, and the adequacy of electroporative current 85.3 %.
conclusionsECT may represent an active and safe treatment to achieve local control in advanced STS patients with symptomatic disease. Future research challenges include the improvement of electrode placement and voltage delivery together with the containment of soft tissue toxicity.
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