Biomarker-guided de-escalation of empirical therapy is associated with lower risk for adverse outcomes.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials.Critical care (London, England) · 2018
   Pooled it
2. Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections.Respiratory research · 2015
   Pooled it
3. Role of procalcitonin use in the management of sepsis.Journal of thoracic disease · 2020
   Review
4. Determining the Clinical Utility of an Absolute Procalcitonin Value for Predicting a Positive Culture Result.Antimicrobial agents and chemotherapy · 2017
   Article
5. Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.Critical care medicine · 2017
   Observational
6. Need for a biomarker to de-escalate antimicrobial empirical therapy.Intensive care medicine · 2014
   Article
7. What can be expected from antimicrobial de-escalation in the critically ill?Intensive care medicine · 2014
   Article

Corrections and comments

• Commented on by
  Need for a biomarker to de-escalate antimicrobial empirical therapy.2014
• Comment on
  De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock.2014

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as