ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2014
Basal ganglia plus insula damage yields stronger disruption of smoking addiction than basal ganglia damage alone.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Distinct brain structural abnormalities in attention-deficit/hyperactivity disorder and substance use disorders: A comparative meta-analysis.Translational psychiatry · 2022Pooled it
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- Smoking-cessation pharmacotherapy for patients with stroke and TIA: Systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Pooled it
- The impacts of actual and perceived nicotine administration on insula functional connectivity with the anterior cingulate cortex and nucleus accumbens.Journal of psychopharmacology (Oxford, England) · 2019Trial
- A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction.Molecular psychiatry · 2026Article
- Determinants of Repetitive Transcranial Magnetic Stimulation Efficacy in Tobacco Use Disorder: A Pre-Registered Study.medRxiv : the preprint server for health sciences · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement.Psychopharmacology · 2024Article
- Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment.The American journal of psychiatry · 2024Review
- Physical Exercise to Redynamize Interoception in Substance use Disorders.Current neuropharmacology · 2024Article
- An Unexpected Outcome of an Ischemic Stroke on the Reward Pathways in the Human Brain.HCA healthcare journal of medicine · 2024Article
- Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective.International journal of molecular sciences · 2023Review
- Nicotine dependence and insula subregions: functional connectivity and cue-induced activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Brain lesions disrupting addiction map to a common human brain circuit.Nature medicine · 2022Article
- The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption.Advances in pharmacology (San Diego, Calif.) · 2022Review
- Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex: A comparison between early-onset smokers and late-onset smokers.Frontiers in psychiatry · 2022Article
- Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder.Frontiers in psychiatry · 2022Review
- Precision Preventive Medicine of Relapse in Smoking Cessation: Can MRI Inform the Search of Intermediate Phenotypes?Biology · 2021Review
- Functional connectivity of the anterior insula during withdrawal from cigarette smoking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionThe main objective of this study was to elucidate the importance of the basal ganglia (BG) and insula (INS) for nicotine addiction and smoking behavior.
methodsWe used a lesion study examining the effects of BG and INS damage on changes in smoking behavior and nicotine dependence over time in a prospective manner. We studied whether combined BG and INS damage yields more substantial disruption of smoking and nicotine dependence than damage to the BG alone and compared with damage to other brain regions outside the BG and INS (brain-damaged comparison [BDC] group). We obtained neuroanatomical and behavioral data for 63 neurological patients with stroke at 1 month after onset and at 3-, 6-, and 12-month follow-ups. All patients were smokers at lesion onset.
resultsThe BG and BG + INS groups had significantly higher and more sustained rates of smoking cessation than patients with damage elsewhere. By 12 months after onset, only 14.3% of the patients in the BDC group were classified as nonsmokers. In the BG group, 37% were not smoking by the 12-month follow-up, and in the BG + INS group, smoking cessation was even more pronounced, as 75% of this group was not smoking at the 12-month epoch.
conclusionsThe findings show that damage to the BG alone can cause disruption of smoking addiction, and when BG damage is combined with INS damage, the disruption increases. The latter finding is consistent with the proposal that the INS has a key role in smoking addiction.
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Registered trials
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