ArticleShock (Augusta, Ga.)2014
Hemostatic function of apheresis platelets stored at 4°C and 22°C.
Article in Shock (Augusta, Ga.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03182946 (Correction of Platelet Dysfunction Following Traumatic Brain Injury in Geriatric Patients), which is not on this map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correction of Platelet Dysfunction Following Traumatic Brain Injury in Geriatric Patients
Who cites it
78 citing papers in PubMed, 254 citations in OpenAlex.
- Platelet dysfunction reversal with cold-stored vs room temperature-stored platelet transfusions.Blood · 2024Trial
- Narrative review of strategies for blood product shelf-life extension.Transfusion · 2026Review
- Transfusion-induced functional and metabolic shifts in stored platelets: limitations of in vitro assessment.Blood vessels, thrombosis & hemostasis · 2026Article
- Bayesian analysis of the early cold stored platelet transfusion following severe injury randomized clinical trial.Trauma surgery & acute care open · 2026Article
- Clot formation and resolution properties of platelets during cold storage for 21 days.Transfusion · 2025Article
- How do we maintain a dual inventory of room temperature stored platelets with cold-stored platelets?Transfusion · 2025Article
- Comparative analysis of cold-stored platelets using Golden Hour transport boxes: Function and quality.Transfusion · 2025Article
- Storage Temperature Affects Platelet Activation and Degranulation in Response to Stimuli.International journal of molecular sciences · 2025Article
- Coagulation and platelet function in cold-stored whole blood on missions in a helicopter emergency service.Acta anaesthesiologica Scandinavica · 2025Article
- Cold vs. Room Temperature: A Comparative Analysis of Platelet Functionality in Cold Storage.Biomedicines · 2025Article
- Cold-stored platelets: revisiting assumptions and addressing variability to support implementation.Frontiers in medicine · 2025Review
- Microfluidic transection injury and high-shear thrombus formation demonstrate increased hemostatic efficacy of cold-stored platelets andFrontiers in bioengineering and biotechnology · 2025Article
- Hemostatic conditions following autologous transfusion of fresh vs stored platelets in experimental endotoxemia: an open-label randomized controlled trial with healthy volunteers.Research and practice in thrombosis and haemostasis · 2024Article
- Stored platelet hemostatic phenotype and function is not altered when donors are on testosterone replacement therapy.Transfusion · 2024Article
- Platelet Storage-Problems, Improvements, and New Perspectives.International journal of molecular sciences · 2024Review
- Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma.Science translational medicine · 2024Article
- In vitro Hemostatic Functions of Cold-Stored Platelets.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Review
- Evaluation of activation characteristics of a canine platelet concentrate produced by a commercial double centrifugation system.Frontiers in veterinary science · 2024Article
- Doing more with less: low-titer group O whole blood resulted in less total transfusions and an independent association with survival in adults with severe traumatic hemorrhage.Journal of thrombosis and haemostasis : JTH · 2024Observational
- Genetically engineered transfusable platelets using mRNA lipid nanoparticles.Science advances · 2023Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionPlatelet refrigeration decreases the risk of bacterial contamination and may preserve function better than standard-of-care room temperature (RT) storage. Benefits could include lower transfusion-related complications, decreased costs, improved hemostasis in acutely bleeding patients, and extended shelf life. In this study, we compared the effects of 22°C and 4°C storage on the functional and activation status of apheresis platelets.
methodsApheresis platelets (n = 5 per group) were stored for 5 days at 22°C with agitation (RT) versus at 4°C with agitation (4°C + AG) and without (4°C). Measurements included platelet counts, mean platelet volume, blood gas analytes, aggregation response, thromboelastography, thromboxane B2 and soluble CD40 ligand release, activation markers, and microparticle formation.
resultsSample pH levels were within acceptable limits for storage products (pH 6.2-7.4). Platelet glucose metabolism (P < 0.05), aggregation response (adenosine diphosphate: RT 0; 4°C + AG 5.0 ± 0.8; 4°C 5.6 ± 0.9; P < 0.05), and clot strength (maximum amplitude: RT 58 ± 2; 4°C + AG 63 ± 2; 4°C 67 ± 2; P < 0.05) were better preserved at 4°C compared with RT storage. Refrigerated samples were more activated compared with RT (P < 0.05), although thromboxane B2 (P < 0.05) and soluble CD40 ligand release (P < 0.05) were higher at RT. Agitation did not improve the quality of 4°C-stored samples.
conclusionsApheresis platelets stored at 4°C maintain more viable metabolic characteristics, are hemostatically more effective, and release fewer proinflammatory mediators than apheresis platelets stored at RT over 5 days. Given the superior bacteriologic safety of refrigerated products, these data suggest that cold-stored platelets may improve outcomes for acutely bleeding patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.