ArticleInvestigative ophthalmology & visual science2013
The rat with oxygen-induced retinopathy is myopic with low retinal dopamine.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.The Journal of pathology · 2026Article
- Beyond Neovascularization: Light Response Deficits in Oxygen-Induced Retinopathy Models.Investigative ophthalmology & visual science · 2026Review
- An APE1 Redox Inhibitor Attenuates Pathological Retinal Vascularization by Suppressing FGF2 Angiogenic Signaling.Investigative ophthalmology & visual science · 2026Article
- Long-Term Impairment of Retinal Ganglion Cell Function After Oxygen-Induced Retinopathy.Cells · 2025Article
- Review
- Electroretinographic Responses in Retinopathy of Prematurity Treated Using Intravitreal Bevacizumab or Laser.American journal of ophthalmology · 2023Article
- Article
- Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia.Neuroscience bulletin · 2022Article
- The role of ipRGCs in ocular growth and myopia development.Science advances · 2022Article
- Prognostic Value Estimation of Monoamines Systemic Level in Retinopathy of Prematurity in Experiment.Sovremennye tekhnologii v meditsine · 2021Article
- Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models.International journal of molecular sciences · 2019Article
- The Role of Catecholamines in the Development of Pathological Retina Neovascularization in an Experimental Model of Retinopathy of Prematurity in Rats.Doklady. Biochemistry and biophysics · 2019Article
- Sustained scleral stiffening in rats after a single genipin treatment.Journal of the Royal Society, Interface · 2019Article
- Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos.The Journal of experimental medicine · 2017Article
- The neural retina in retinopathy of prematurity.Progress in retinal and eye research · 2017Review
- Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy.The American journal of pathology · 2016Article
- Altered Refractive Development in Mice With Reduced Levels of Retinal Dopamine.Investigative ophthalmology & visual science · 2016Article
- Vulnerability of Dopaminergic Amacrine Cells to Chronic Ischemia in a Mouse Model of Oxygen-Induced Retinopathy.Investigative ophthalmology & visual science · 2016Article
- Retinal, visual, and refractive development in retinopathy of prematurity.Eye and brain · 2016Review
- Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain.Frontiers in cellular neuroscience · 2015Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeDopamine (DA) is a neurotransmitter implicated both in modulating neural retinal signals and in eye growth. Therefore, it may participate in the pathogenesis of the most common clinical sequelae of retinopathy of prematurity (ROP), visual dysfunction and myopia. Paradoxically, in ROP myopia the eye is usually small. The eye of the rat with oxygen-induced retinopathy (OIR) is characterized by retinal dysfunction and short axial length. There have been several investigations of the early maturation of DA in rat retina, but little at older ages, and not in the OIR rat. Therefore, DA, retinal function, and refractive state were investigated in the OIR rat.
methodsIn one set of rats, the development of dopaminergic (DAergic) networks was evaluated in retinal cross-sections from rats aged 14 to 120 days using antibodies against tyrosine hydroxylase (TH, the rate-limiting enzyme in the biosynthesis of DA). In another set of rats, retinoscopy was used to evaluate spherical equivalent (SE), electoretinography (ERG) was used to evaluate retinal function, and high-pressure liquid chromatography (HPLC) was used to evaluate retinal contents of DA, its precursor levodopamine (DOPA), and its primary metabolite 3,4-dihydroxyphenylacetic acid (DOPAC).
resultsThe normally rapid postnatal ramification of DAergic neurons was disrupted in OIR rats. Retinoscopy revealed that OIR rats were relatively myopic. In the same eyes, ERG confirmed retinal dysfunction in OIR. HPLC of those eyes' retinae confirmed low DA. Regression analysis indicated that DA metabolism (evaluated by the ratio of DOPAC to DA) was an important additional predictor of myopia beyond OIR.
conclusionsThe OIR rat is the first known animal model of myopia in which the eye is smaller than normal. Dopamine may modulate, or fail to modulate, neural activity in the OIR eye, and thus contribute to this peculiar myopia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.