ArticleEnvironmental health perspectives2014
Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
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- GM-CSF-dependent CD301bNature communications · 2025Article
- Harnessing the Farm Effect: Microbial Products for the Treatment and Prevention of Asthma Throughout Life.Immunological reviews · 2025Review
- Eos Promotes TH2 Differentiation by Interacting with and Propagating the Activity of STAT5.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Catching Our Breath: Updates on the Role of Dendritic Cell Subsets in Asthma.Advanced biology · 2023Review
- Bioinformatic analysis and experimental validation of the potential gene in the airway inflammation of steroid-resistant asthma.Scientific reports · 2023Article
- A neutrophil/TGF-β axis limits the pathogenicity of allergen-specific CD4+ T cells.JCI insight · 2022Article
- CD11bNature communications · 2021Article
- Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models.PloS one · 2021Article
- Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.Cell reports · 2020Article
- Role of Environmental Adjuvants in Asthma Development.Current allergy and asthma reports · 2020Review
- Article
- Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Pathogenic TThe Journal of allergy and clinical immunology · 2018Article
- Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes.Stem cell research & therapy · 2018Article
- Long-term exposure to low-doseOncotarget · 2018Article
- NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.The Journal of allergy and clinical immunology · 2017Article
- The TLR4-TRIF pathway can protect against the development of experimental allergic asthma.Immunology · 2017Article
- The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma.Mediators of inflammation · 2017Review
- Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?Mediators of inflammation · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHumans with asthma display considerable heterogeneity with regard to T helper (Th) 2-associated eosinophilic and Th17-associated neutrophilic inflammation, but the impact of the environment on these different forms of asthma is poorly understood.
objectiveWe studied the nature and longevity of asthma-like responses triggered by inhalation of allergen together with environmentally relevant doses of inhaled lipopolysaccharide (LPS).
methodsOvalbumin (OVA) was instilled into the airways of mice together with a wide range of LPS doses. Following a single OVA challenge, or multiple challenges, animals were assessed for pulmonary cytokine production, airway inflammation, and airway hyperresponsiveness (AHR).
resultsMice instilled with OVA together with very low doses (≤10⁻³ μg) of LPS displayed modest amounts of Th2 cytokines, with associated airway eosinophilia and AHR after a single challenge, and these responses were sustained after multiple OVA challenges. When the higher but still environmentally relevant dose of 10⁻¹ μg LPS was used, mice initially displayed similar Th2 responses, as well as Th17-associated neutrophilia. After multiple OVA challenges, however, the 10⁻¹ μg LPS animals also accumulated large numbers of allergen-specific T regulatory (Treg) cells with high levels of inducible co-stimulatory molecule (ICOS). As a result, asthma-like features in these mice were shorter-lived than in mice sensitized using lower doses of LPS.
conclusionsThe nature and longevity of Th2, Th17, and Treg immune responses to inhaled allergen are dependent on the quantity of LPS inhaled at the time of allergic sensitization. These findings might account in part for the heterogeneity of inflammatory infiltrates seen in lungs of asthmatics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.