ArticleACS chemical biology2013
Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
Article in ACS chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
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- Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.Cell chemical biology · 2025Article
- Distinct profiles of osteoclast and dendritic cell-mediated expansion and functional activation of NK and T cells.Cancer immunology, immunotherapy : CII · 2025Article
- Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19.International journal of molecular sciences · 2021Review
- Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non-medullary thyroid cancer.Cellular oncology (Dordrecht, Netherlands) · 2021Article
- Autophagy Induced by the N-Terminus of the Classic Swine Fever Virus Nonstructural Protein 5A Protein Promotes Viral Replication.Frontiers in microbiology · 2021Article
- Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells.Scientific reports · 2020Article
- Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections.Cells · 2020Article
- Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis.Journal of inflammation (London, England) · 2020Review
- Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease.FASEB bioAdvances · 2019Article
- Article
- Identification of natural products with neuronal and metabolic benefits through autophagy induction.Autophagy · 2017Article
- Microglia and Monocyte-Derived Macrophages in Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Targeted pulmonary delivery of inducers of host macrophage autophagy as a potential host-directed chemotherapy of tuberculosis.Advanced drug delivery reviews · 2016Review
- Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.Immunity · 2016Article
- Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.Cancer immunology research · 2016Article
- Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.Scientific reports · 2016Article
- The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.eLife · 2016Article
- The Mucosal Immune System and Its Regulation by Autophagy.Frontiers in immunology · 2016Review
- Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.Nature communications · 2015Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
Autophagy is an evolutionarily conserved catabolic process that directs cytoplasmic proteins, organelles and microbes to lysosomes for degradation. Autophagy acts at the intersection of pathways involved in cellular stress, host defense, and modulation of inflammatory and immune responses; however, the details of how the autophagy network intersects with these processes remain largely undefined. Given the role of autophagy in several human diseases, it is important to determine the extent to which modulators of autophagy also modify inflammatory or immune pathways and whether it is possible to modulate a subset of these pathways selectively. Here, we identify small-molecule inducers of basal autophagy (including several FDA-approved drugs) and characterize their effects on IL-1β production, autophagic engulfment and killing of intracellular bacteria, and development of Treg, TH17, and TH1 subsets from naïve T cells. Autophagy inducers with distinct, selective activity profiles were identified that reveal the functional architecture of connections between autophagy, and innate and adaptive immunity. In macrophages from mice bearing a conditional deletion of the essential autophagy gene Atg16L1, the small molecules inhibit IL-1β production to varying degrees suggesting that individual compounds may possess both autophagy-dependent and autophagy-independent activity on immune pathways. The small molecule autophagy inducers constitute useful probes to test the contributions of autophagy-related pathways in diseases marked by impaired autophagy or elevated IL-1β and to test novel therapeutic hypotheses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.