ArticleISRN oncology2013
Evaluation of the benefit of routine intraoperative frozen section analysis of sentinel lymph nodes in breast cancer.
Article in ISRN oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Omission of intraoperative frozen section in sentinel lymph node biopsy for early breast cancer: impact on survival outcomes.Gland surgery · 2026Article
- Predictors of recurrence in breast cancer patients with pathological partial response.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma.Annual review of pathology · 2023Review
- A nomogram for predicting three or more axillary lymph node involvement before breast cancer surgery.Scientific reports · 2022Article
- Critical Review of the Current Evidence on Sentinel Node Biopsy in Oral Cancer.Current oncology reports · 2022Review
- Evolution of Frozen Section in Carcinoma Breast: Systematic Review.International journal of breast cancer · 2022Review
- After neoadjuvant therapy, axillary sentinel lymph node frozen sections from breast cancer patients are accurately diagnosed using telepathology.Journal of pathology informatics · 2022Article
- Is the intraoperative frozen section analysis of sentinel lymph nodes necessary in clinically negative node breast cancer?Annals of surgical treatment and research · 2020Article
- Is the frozen section examination for sentinel lymph node necessary in early breast cancer patients?Annals of surgical treatment and research · 2019Article
- The Empirical Foundations of Telepathology: Evidence of Feasibility and Intermediate Effects.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2017Review
- Results from Survey to Assess Current Trends in Surgical Practice in the Management of Women with Early Stage Cervical Cancer within the BGCS Community with an Emphasis on Routine Frozen Section Examination.International journal of surgical oncology · 2017Article
- Secretory breast carcinoma in a 12-year-old girl: A case report.Oncology letters · 2014Article
- An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims. Intraoperative analysis of the sentinel lymph node (SLN) by frozen section (FS) allows for immediate axillary lymph node dissection (ALND) in case of metastatic disease in patients with breast cancer. The aim of this study is to evaluate the benefit of intraoperative FS, with regard to false negative rate (FNR) and influence on operation time. Materials and Methods. Intraoperative analysis of the SLN by FS was performed on 628 patients between January 2005 and October 2009. Patients were retrospectively studied. Results. FS accurately predicted axillary status in 525 patients (83.6%). There were 78 true positive findings (12.4%), of which there are 66 macrometastases (84.6%), 2 false positive findings (0.3%), and 101 false negative findings (16.1%), of which there are 65 micrometastases and isolated tumour cells (64.4%) resulting in an FNR of 56.4%. Additional operation time of a secondary ALND after wide local excision and SLNB is 17 minutes, in case of ablative surgery 35 minutes. The SLN was negative in 449 patients (71.5%), making their scheduled operation time unnecessary. Conclusions. FS was associated with a high false negative rate (FNR) in our population, and the use of telepathology caused an increase in this rate. Only 12.4% of the patients benefited from intraoperative FS, as secondary ALND could be avoided, so FS may be indicated for a selected group of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.