ArticleTherapeutic advances in psychopharmacology2013
Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem.
Article in Therapeutic advances in psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Characterizing post-mortem blood concentrations in methadone-related deaths.International journal of legal medicine · 2026Pooled it
- Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.Psychopharmacology · 2013Pooled it
- Article
- Article
- The Role of Risk or Contributory Death Factors in Methadone-Related Fatalities: A Review and Pooled Analysis.Metabolites · 2021Article
- Synthetic cannabinoids and potential cardiac arrhythmia risk: an important message for drug users.Therapeutic advances in drug safety · 2020Article
- Practical Pharmacology of Methadone: A Long-acting Opioid.Indian journal of palliative care · 2018Review
- Need for a more developmental perspective: QTc prolongation under psychotropic medication.European child & adolescent psychiatry · 2017Article
- Humans Vary, So Cardiac Models Should Account for That Too!Frontiers in physiology · 2017Review
- Cardiovascular disease among people with drug use disorders.International journal of public health · 2015Article
- QTc Prolongation in Veterans With Heroin Dependence on Methadone Maintenance Treatment.International journal of high risk behaviors & addiction · 2015Article
- A systematic review of the cardiotoxicity of methadone.EXCLI journal · 2015Review
- Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports.Therapeutic advances in psychopharmacology · 2014Review
- Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity.Therapeutic advances in infectious disease · 2014Article
- Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: A narrative review based on the study of case reports.Therapeutic advances in infectious disease · 2013Article
- Clarithromycin, QTc interval prolongation and torsades de pointes: the need to study case reports.Therapeutic advances in infectious disease · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reviewed the literature and found 31 adult cases and 1 newborn case of methadone-associated QTc interval prolongation and/or torsade de pointes (TdP). Parametric statistics may not be useful in studying this issue because methadone-associated TdP is a very rare event and, hence, "an extreme outlier" consistent with scalable randomness. We may have to rely upon narrative medicine in the form of case reports with all its limitations and hazards to provide our best understanding. We report risk factors for methadone-associated QTc interval prolongation and TdP based on review of published case reports. We believe both drug manufacturers and the FDA would better serve our patients and inform clinicians if they more readily reported drug-induced outliers such as methadone-associated TdP using a case report format.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.