Trial reportPloS one2013
Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Septic pulmonary embolism in Somali children: a retrospective study from a tertiary hospital.Frontiers in pediatrics · 2026Article
- Decoding Ocimum basilicum L.'s Medicinal Potential Through Growth Phase Profiling: A Conservation Perspective.Chemistry & biodiversity · 2026Article
- Staphylococcus aureus bloodstream infection at a referral children's hospital in Cape Town, South Africa, 2018-2022.BMC infectious diseases · 2025Article
- Community-acquired Staphylococcus aureus bacteremia in healthy children-13 years of experience in a pediatric tertiary center.European journal of pediatrics · 2025Article
- The importance of "one health approach" to the AMR study and surveillance in Angola and other African countries.One health (Amsterdam, Netherlands) · 2024Review
- Analysis of the Trends of Methicillin-Resistant Staphylococcus aureus in Gauteng Public Hospitals from 2009 to 2018.Microbiology spectrum · 2023Article
- Epidemiology and clinical presentation of community-acquired Staphylococcus aureus bacteraemia in children under 5 years of age admitted to the Manhiça District Hospital, Mozambique, 2001-2019.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- A descriptive study of vancomycin use at Red Cross War Memorial Children's Hospital, Cape Town.Southern African journal of infectious diseases · 2023Article
- Prevalence ofSouthern African journal of infectious diseases · 2023Article
- Human-Associated Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- A retrospective analysis of community-onset bloodstream infections at a tertiary-care academic hospital in South Africa. Are current empiric antimicrobial practices appropriate?Antimicrobial stewardship & healthcare epidemiology : ASHE · 2021Article
- Molecular Characterization and Pathogenicity ofMicroorganisms · 2020Article
- Reducing transmission of methicillin-resistantInfection prevention in practice · 2019Article
- Community-acquired Invasive Bacterial Disease in Urban Gambia, 2005-2015: A Hospital-based Surveillance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Infection characteristics and treatment of Staphylococcus aureus bacteraemia at a tertiary children's hospital.BMC infectious diseases · 2018Article
- Systematic review in South Africa reveals antibiotic resistance genes shared between clinical and environmental settings.Infection and drug resistance · 2018Review
- Prevalence ofThe American journal of tropical medicine and hygiene · 2017Article
- Patterns and trends of pediatric bloodstream infections: a 7-year surveillance study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Observational
- Article
- Klebsiella pneumoniae bloodstream infections at a South African children's hospital 2006-2011, a cross-sectional study.BMC infectious diseases · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia, however, has not been well documented in children in South Africa.
methodsA retrospective study was conducted at a children's hospital in Cape Town, South Africa, to investigate the epidemiology of S. aureus bacteraemia from 2007-2011. The incidence, clinical presentation, risk factors, management and outcomes of methicillin sensitive S. aureus (MSSA) and methicillin resistant S. aureus (MRSA) bacteraemia were compared.
resultsOver the five year study period, 365 episodes of S. aureus bacteraemia were identified. The annual incidence was 3.28 cases per 1000 hospital admissions. MRSA was responsible for 26% of S. aureus bacteraemia and 72% of nosocomial infections. Only six possible cases of community-acquired MRSA infections were described. MSSA bacteraemia was more likely to present as pulmonary and bone or joint infections, while bacteraemia without a source was the most common presentation with MRSA. Infants, children with malnutrition, and residents of long-term care facilities were at highest risk for MRSA bacteraemia. The overall case fatality rate for S. aureus bacteraemia was 8.8% over five years, with MRSA being the only significant risk factor for mortality.
conclusionThe incidence of S. aureus bacteraemia and MRSA bacteraemia in children has remained stable over the past five years. MRSA is a predominantly nosocomial pathogen in children with S. aureus bacteraemia in Cape Town, South Africa.
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