Evidence map›Paper›PMID 24167602›Full record

Trial reportPloS one2013

A fast and cost-effective method for identifying a polymorphism of interleukin 28B related to hepatitis C.

Camila da Silva Ferreira, Rodrigo Martins Abreu, Marlone Cunha da Silva, Aline Siqueira Ferreira, Paulo Dominguez Nasser, Flair José Carrilho, Suzane Kioko Ono

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Camila da Silva FerreiraUniversity of São Paulo School of Medicine, Department of Gastroenterology, São Paulo, SP, Brazil.
Rodrigo Martins Abreu
Marlone Cunha da Silva
Aline Siqueira Ferreira
Paulo Dominguez Nasser
Flair José Carrilho
Suzane Kioko Ono
Universidade de São Paulo · BRUniversidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 170 million people are chronic carriers of hepatitis C virus (HCV). Patients with chronic hepatitis C are currently treated with pegylated interferon and ribavirin (PEG-IFN/RBV). A genome-wide association with PEG-IFN/RBV treatment response and a single nucleotide polymorphism (rs12979860) has been identified near the interleukin 28B gene that encodes interferon-λ-3. In this paper, we describe an innovative, fast, and low-cost multiplex polymerase chain reaction with confronting two-pair primers that detects the rs12979860 polymorphism. The assay is internally controlled and does not require the use of restriction endonucleases or special equipment. Moreover, the assay decreases costs, being about 40% cheaper than direct sequencing methods.

Indexed as

Polymorphism, Single NucleotideAdultDNA PrimersFemaleGenome-Wide Association StudyHepatitis C, ChronicHumansInterferon LambdaInterferonsInterleukinsMaleMiddle AgedMultiplex Polymerase Chain ReactionDNA PrimersInterferon Lambdainterferon-lambda, humanInterferonsInterleukins

Identifiers

PMID24167602
PMCPMC3805516
OpenAlexW2059350964

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.