ArticleDisease markers2013
Reduced paraoxonase 1 activity as a marker for severe coronary artery disease.
Article in Disease markers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03646019 (Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum Oxidative Status as a Potential Predictor of Coronary Artery Disease.
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Role of antioxidant property of carvedilol in mild to moderate hypertensive patients: A prospective open-label study.Indian journal of pharmacologyTrial
- Tetranectin and Paraoxonase-1 as Markers of Heart Failure.Medicina (Kaunas, Lithuania) · 2026Review
- Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes.Frontiers in endocrinology · 2026Article
- miR-122/PPARβ axis is involved in hypoxic exercise and modulates fatty acid metabolism in skeletal muscle of obese rats.Heliyon · 2024Article
- Article
- Hepatic paraoxonase 1 ameliorates dysfunctional high-density lipoprotein and atherosclerosis in scavenger receptor class B type I deficient mice.Annals of translational medicine · 2021Article
- The Antioxidant Enzyme PON1: A Potential Prognostic Predictor of Acute Ischemic Stroke.Oxidative medicine and cellular longevity · 2021Article
- Inhibition of miR-27b Regulates Lipid Metabolism in Skeletal Muscle of Obese Rats During Hypoxic Exercise by Increasing PPARγ Expression.Frontiers in physiology · 2020Article
- Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study.Open access rheumatology : research and reviews · 2020Article
- Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice.Journal of translational medicine · 2018Article
- Decreases in Paraoxonase-1 Activities Promote a Pro-inflammatory Effect of Lipids Peroxidation Products in Non-smoking and Smoking Patients with Acute Pancreatitis.International journal of medical sciences · 2018Article
- Protective effects of Xiongshao Capsule () on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model.Chinese journal of integrative medicine · 2017Article
- Relationship between rs854560Disease markers · 2017Article
- Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice.International journal of molecular sciences · 2016Article
- Serum paraoxonase 1 activity in patients with iron deficiency anemia.Archives of medical science : AMS · 2016Article
- A human apolipoprotein E mimetic peptide reduces atherosclerosis in aged apolipoprotein E null mice.American journal of translational research · 2016Article
- Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice.Journal of lipid research · 2015Article
- PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice.Journal of translational medicine · 2015Article
- Antioxidant and lipid-regulating effects of probucol combined with atorvastatin in patients with acute coronary syndrome.Journal of thoracic disease · 2015Article
- Association between Paraoxonase 1 (PON1) Polymorphisms and the Risk of Acute Coronary Syndrome in a North African Population.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraoxonase-1 (PON1), a high-density-lipoprotein- (HDL-) associated enzyme, has the potential to protect against atherogenesis. We examine the relationships between plasma PON1 activity and the progression of atherosclerosis as well as coronary artery disease (CAD). Fasting blood samples were collected from female apolipoprotein E-deficient (apoE(-/-)) mice and 149 patients undergoing coronary angiography for the biochemical parameters measurement. The severity of CAD was defined using angiographic Gensini score (GSS). Compared to 3-month-old apoE(-/-) mice, aged mice had significantly lower PON1 activity, which is negatively correlated with the size of atherosclerotic lesion and plasma interleukin-6 (IL-6) and tumor necrosis factor α (TNF- α ) levels. In study patients, PON1 activity was correlated with age, sex, and HDL-cholesterol, apolipoprotein AI, and high-sensitivity C-reactive protein (hs-CRP) levels and was significantly lower in CAD group than that in non-CAD control group. Interestingly, PON1 activity in severe CAD group (GSS > 40) was further significantly reduced compared to those in mild and moderate subgroups (GSS ≤ 40) (P < 0.01). There is a significant correlation between PON1 activity and the severity of CAD as assessed by GSS (r = -0.393, P < 0.001). PON1 activity may be a potential biomarker for the severity of CAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.