Evidence map›Paper›PMID 24167223›Full record

Trial reportThe Journal of physiology2013

Exercise counteracts the effects of short-term overfeeding and reduced physical activity independent of energy imbalance in healthy young men.

Jean-Philippe Walhin, Judith D Richardson, James A Betts, Dylan Thompson

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02333916 (Effects of Short-term Overfeeding With or Without Exercise on 24-hour Fat Oxidation and Fat Balance Before and After 10 Weeks of Training - The FeedEX Study), which is not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02333916 naterminatednot on this mapstarted 2014, after this paper: background citation

Effects of Short-term Overfeeding With or Without Exercise on 24-hour Fat Oxidation and Fat Balance Before and After 10 Weeks of Training - The FeedEX Study

TypeinterventionalSponsorMaastricht University Medical CenterRan2014Enrolled5ConditionsOverfeeding and ExerciseArmsoverfeeding + exercise pre-training, fitness training, overfeeding + exercise post-training
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. The Impact of Long-term Physical Inactivity on Adipose Tissue Immunometabolism.The Journal of clinical endocrinology and metabolism · 2022
    Trial
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  8. Metabolic Implications of Diet and Energy Intake during Physical Inactivity.Medicine and science in sports and exercise · 2019
    Trial
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  14. Trial
  15. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jean-Philippe WalhinD. Thompson: Department for Health, University of Bath, Bath BA2 7AY, UK. d.thompson@bath.ac.uk.
Judith D Richardson
James A Betts
Dylan Thompson
University of Bath · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity can affect many aspects of metabolism but it is unclear to what extent this relies on manipulation of energy balance. Twenty-six active men age 25 ± 7 years (mean ± SD) were randomly assigned either to consume 50% more energy than normal by over-consuming their habitual diet for 7 days whilst simultaneously restricting their physical activity below 4000 steps day(-1) to induce an energy surplus (SUR group; n = 14) or to the same regimen but with 45 min of daily treadmill running at 70% of maximum oxygen uptake (SUR+EX group; n = 12). Critically, the SUR+EX group received additional dietary energy intake to account for the energy expended by exercise, thus maintaining a matched energy surplus. At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted. Insulinaemic responses to a standard glucose load increased 2-fold from baseline to follow-up in the SUR group (17 ± 16 nmol (120 min) l(-1); P = 0.002) whereas there was no change in the SUR+EX group (1 ± 6 nmol (120 min) l(-1)). Seven of 17 genes within adipose tissue were differentially expressed in the SUR group; expression of SREBP-1c, FAS and GLUT4 was significantly up-regulated and expression of PDK4, IRS2, HSL and visfatin was significantly down-regulated (P ≤ 0.05). The pAMPK/AMPK protein ratio in adipose tissue was significantly down-regulated in the SUR group (P = 0.005). Vigorous-intensity exercise counteracted most of the effects of short-term overfeeding and under-activity at the whole-body level and in adipose tissue, even in the face of a standardised energy surplus.

Indexed as

Energy IntakeEnergy MetabolismExerciseAdipose TissueAdolescentAdultDown-Regulationfas ReceptorFastingGlucose IntoleranceGlucose Transporter Type 4HomeostasisHumansInsulin Receptor Substrate ProteinsMaleNicotinamide PhosphoribosyltransferaseFAS protein, humanfas ReceptorGlucose Transporter Type 4Insulin Receptor Substrate ProteinsIRS2 protein, humanNicotinamide PhosphoribosyltransferasePDK4 protein, humanProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseSterol EsteraseSterol Regulatory Element Binding Protein 1

Identifiers

PMID24167223
PMCPMC3892474
OpenAlexW2162441719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.