Trial reportPediatrics2013
Hypospadias and residential proximity to pesticide applications.
Trial report in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Glyphosate and adverse pregnancy outcomes, a systematic review of observational studies.BMC public health · 2016Pooled it
- Review
- Maternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.Frontiers in public health · 2024Article
- Group Psychotherapy for Parents of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome.Journal of clinical psychology in medical settings · 2023Article
- The Changing Climate and Pregnancy Health.Current environmental health reports · 2022Review
- Maternal Exposure to Disinfection By-Products and Risk of Hypospadias in the National Birth Defects Prevention Study (2000-2005).International journal of environmental research and public health · 2020Article
- The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF.Endocrine connections · 2020Review
- Bisphenols and Leydig Cell Development and Function.Frontiers in endocrinology · 2020Review
- Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.Birth defects research · 2019Article
- [Endocrine disruptors and hypospadias in Gran Canaria island (2012-2015)].Revista espanola de salud publica · 2018Article
- Association of pesticide exposure with human congenital abnormalities.Toxicology and applied pharmacology · 2018Review
- Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line.Toxicology reports · 2018Article
- Sex-dependent impact of Roundup on the rat gut microbiome.Toxicology reports · 2018Article
- Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide.Scientific reports · 2017Article
- Ignoring Adjuvant Toxicity Falsifies the Safety Profile of Commercial Pesticides.Frontiers in public health · 2017Review
- Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring.International journal of environmental research and public health · 2016Article
- Joint effects of genetic variants and residential proximity to pesticide applications on hypospadias risk.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa).Environmental health perspectives · 2016Article
- Do endocrine disruptors cause hypospadias?Translational andrology and urology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundExperimental evidence suggests pesticides may be associated with hypospadias.
objectiveExamine the association of hypospadias with residential proximity to commercial agricultural pesticide applications.
methodsThe study population included male infants born from 1991 to 2004 to mothers residing in 8 California counties. Cases (n = 690) were ascertained by the California Birth Defects Monitoring Program; controls were selected randomly from the birth population (n = 2195). We determined early pregnancy exposure to pesticide applications within a 500-m radius of mother's residential address, using detailed data on applications and land use. Associations with exposures to physicochemical groups of pesticides and specific chemicals were assessed using logistic regression adjusted for maternal race or ethnicity and age and infant birth year.
resultsForty-one percent of cases and controls were classified as exposed to 57 chemical groups and 292 chemicals. Despite >500 statistical comparisons, there were few elevated odds ratios with confidence intervals that excluded 1 for chemical groups or specific chemicals. Those that did were for monochlorophenoxy acid or ester herbicides; the insecticides aldicarb, dimethoate, phorate, and petroleum oils; and adjuvant polyoxyethylene sorbitol among all cases; 2,6-dinitroaniline herbicides, the herbicide oxyfluorfen, and the fungicide copper sulfate among mild cases; and chloroacetanilide herbicides, polyalkyloxy compounds used as adjuvants, the insecticides aldicarb and acephate, and the adjuvant nonyl-phenoxy-poly(ethylene oxy)ethanol among moderate and severe cases. Odds ratios ranged from 1.9 to 2.9.
conclusionsMost pesticides were not associated with elevated hypospadias risk. For the few that were associated, results should be interpreted with caution until replicated in other study populations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.