Evidence map›Paper›PMID 24167175›Full record

SynthesisPediatrics2013

Cognitive-behavioral therapy for anxiety in children with high-functioning autism: a meta-analysis.

Denis G Sukhodolsky, Michael H Bloch, Kaitlyn E Panza, Brian Reichow

3 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 93 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02225808 nacompletednot on this mapstarted 2014, after this paper: background citation

Neural Mechanisms of Cognitive-Behavioral Therapy for Anxiety in Children With Autism Spectrum Disorder: A Pilot Study

TypeinterventionalSponsorYale UniversityRan2014 to 2016Enrolled10ConditionsAutism, Autism Spectrum Disorder, AnxietyArmsCBT for anxiety in autism
NCT02725619 nacompletednot on this mapstarted 2016, after this paper: background citation

Neural Mechanisms of CBT for Anxiety in Children With Autism: Randomized Controlled Trial

TypeinterventionalSponsorYale UniversityRan2016 to 2022Enrolled70ConditionsAutism Spectrum Disorder, AnxietyArmsCBT, PST
NCT03279471 phase2completednot on this mapstarted 2017, after this paper: background citation

Specifying and Treating the Anxiety Phenotype in Autism Spectrum Disorder

TypeinterventionalSponsorUniversity of California, DavisRan2017 to 2023Enrolled68ConditionsAutism Spectrum Disorder, AnxietyArmsSertraline, CBT/BIACA, Placebo
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Meta-analysis of Psychotherapy for Autistic Youth.Child psychiatry and human development · 2026
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  8. Family therapy for autism spectrum disorders.The Cochrane database of systematic reviews · 2017
    Pooled it
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  11. Trial
  12. Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People.Autism research : official journal of the International Society for Autism Research · 2026
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  20. Guided self-help for depression in autistic adults: the ADEPT feasibility RCT.Health technology assessment (Winchester, England) · 2019
    Trial

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Denis G SukhodolskyYale Child Study Center, 230 South Frontage Road, New Haven, CT 06520. denis.sukhodolsky@yale.edu.
Michael H Bloch
Kaitlyn E Panza
Brian Reichow

Funding

Research Training for Medical Students & Physician-Scientists in Child PsychiatryR25MH077823 · NIMH · YALE UNIVERSITY · PI ANDRES S MARTIN · 2006 to 2026
$4.0M
Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum DisorderR01HD083881 · NICHD · YALE UNIVERSITY · PI PELPHREY, KEVIN A, SUKHODOLSKY, DENIS G · 2016 to 2020
$2.8M
Longitudinal Structural MRI Study of Adulthood Outcome in Tourette SyndromeK23MH091240 · NIMH · YALE UNIVERSITY · PI BLOCH, MICHAEL H · 2010 to 2014
$902k
Neurobiology of Behavior Therapy for Children with Tourette SyndromeK01MH079130 · NIMH · YALE UNIVERSITY · PI SUKHODOLSKY, DENIS G · 2008 to 2012
$833k
NICHD NIH HHS R01 HD083881NIMH NIH HHS K01 MH079130NIMH NIH HHS K23 MH091240NIMH NIH HHS K23MH091240NIMH NIH HHS R25 MH077823
6 · The paper itself

Abstract

backgroundAnxiety is a common and impairing problem in children and adolescents with autism spectrum disorder (ASD). There is emerging evidence that cognitive-behavioral therapy (CBT) could reduce anxiety in children with high-functioning ASD.

objectiveTo systematically review the evidence of using CBT to treat anxiety in children and adolescents with ASD. Methods for this review were registered with PROSPERO (CRD42012002722).

methodsWe included randomized controlled trials published in English in peer-reviewed journals comparing CBT with another treatment, no treatment control, or waitlist control. Two authors independently screened 396 records obtained from database searches and hand searched relevant journals. Two authors independently extracted and reconciled all data used in analyses from study reports.

resultsEight studies involving 469 participants (252 treatment, 217 comparison) met our inclusion criteria and were included in meta-analyses. Overall effect sizes for clinician- and parent-rated outcome measures of anxiety across all studies were d = 1.19 and d = 1.21, respectively. Five studies that included child self-report yielded an average d = 0.68 across self-reported anxiety.

conclusionsParent ratings and clinician ratings of anxiety are sensitive to detecting treatment change with CBT for anxiety relative to waitlist and treatment-as-usual control conditions in children with high-functioning ASD. Clinical studies are needed to evaluate CBT for anxiety against attention control conditions in samples of children with ASD that are well characterized with regard to ASD diagnosis and co-occurring anxiety symptoms.

Indexed as

AnxietyAutistic DisorderChildCognitive Behavioral TherapyHumansRandomized Controlled Trials as Topicadolescentsanxietyautism spectrum disorderchildrencognitive–behavior therapymeta-analysisrandomized controlled trial

Identifiers

PMID24167175
PMCPMC3813396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.