ArticlePediatrics2013
Narrow vs broad-spectrum antimicrobial therapy for children hospitalized with pneumonia.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Treatment of mild to moderate community-acquired pneumonia in previously healthy children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG-SIMG).Italian journal of pediatrics · 2024Pooled it
- Differences in antibiotic treatment for children hospitalized with pneumonia.Journal of hospital medicine · 2026Article
- Children Hospitalized With Pneumonia Who Complete Oral Antibiotic Treatment Without Complications.Hospital pediatrics · 2026Article
- AI-driven diagnosis of pneumococcal infections in children-a call for primary-care focused and a coherent evidence base.Frontiers in artificial intelligence · 2026Review
- Comparison of the effectiveness of penicillin and broad-spectrum β-lactam antibiotics in the treatment of community-acquired pneumonia in children.Archives of medical science : AMS · 2026Article
- Antibiotic Usage for Treatment of Acute Upper Respiratory Tract Infections in Children in Lithuania from 2018 to 2022.Antibiotics (Basel, Switzerland) · 2025Article
- Association between initial antibiotic route and outcomes for children hospitalized with pneumonia.Journal of hospital medicine · 2025Article
- Antibiotic route and outcomes for children hospitalized with pneumonia.Journal of hospital medicine · 2024Article
- ImprovingAntibiotics (Basel, Switzerland) · 2024Article
- Evaluation of a Pediatric Community-Acquired Pneumonia Antimicrobial Stewardship Intervention at an Academic Medical Center.Antibiotics (Basel, Switzerland) · 2023Article
- The development of a novel natural language processing tool to identify pediatric chest radiograph reports with pneumonia.Frontiers in digital health · 2023Article
- Outpatient antibiotic prescribing for acute respiratory infections in Vietnamese primary care settings by the WHO AWaRe (Access, Watch and Reserve) classification: An analysis using routinely collected electronic prescription data.The Lancet regional health. Western Pacific · 2023Article
- Variation in bacterial pneumonia diagnoses and outcomes among children hospitalized with lower respiratory tract infections.Journal of hospital medicine · 2022Article
- Risk of antibiotic treatment failure in premenopausal women with uncomplicated urinary tract infection.Pharmacoepidemiology and drug safety · 2021Article
- Observational
- Combined influence of practice guidelines and prospective audit and feedback stewardship on antimicrobial treatment of community-acquired pneumonia and empyema in children: 2012 to 2016.Paediatrics & child health · 2021Article
- Antibiotic Choice and Clinical Outcomes in Ambulatory Children with Community-Acquired Pneumonia.The Journal of pediatrics · 2021Article
- Comparative analysis of the effectiveness of narrow-spectrum versus broad-spectrum antibiotics for the treatment of childhood pneumonia.SAGE open medicine · 2021Article
- Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A multicentre observational study.PLoS medicine · 2020Observational
- Improving antibiotic prescribing in the emergency department for uncomplicated community-acquired pneumonia.World journal of emergency medicine · 2020Article
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Authors and funding
10 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundThe 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America community-acquired pneumonia (CAP) guideline recommends narrow-spectrum antimicrobial therapy for most children hospitalized with CAP. However, few studies have assessed the effectiveness of this strategy.
methodsUsing data from 43 children's hospitals, we conducted a retrospective cohort study to compare outcomes and resource utilization among children hospitalized with CAP between 2005 and 2011 receiving either parenteral ampicillin/penicillin (narrow spectrum) or ceftriaxone/cefotaxime (broad spectrum). Children with complex chronic conditions, interhospital transfers, recent hospitalization, or the occurrence of any of the following during the first 2 calendar days of hospitalization were excluded: pleural drainage procedure, admission to intensive care, mechanical ventilation, death, or hospital discharge.
resultsOverall, 13,954 children received broad-spectrum therapy (89.7%) and 1610 received narrow-spectrum therapy (10.3%). The median length of stay was 3 days (interquartile range 3-4) in the broad- and narrow-spectrum therapy groups (adjusted difference 0.12 days, 95% confidence interval [CI]: -0.02 to 0.26). One hundred fifty-six children (1.1%) receiving broad-spectrum therapy and 13 children (0.8%) receiving narrow-spectrum therapy were admitted to intensive care (adjusted odds ratio 0.85, 95% CI: 0.27 to 2.73). Readmission occurred for 321 children (2.3%) receiving broad-spectrum therapy and 39 children (2.4%) receiving narrow-spectrum therapy (adjusted odds ratio 0.85, 95% CI: 0.45 to 1.63). Median costs for the hospitalization were $3992 and $4375 (adjusted difference -$14.4, 95% CI: -177.1 to 148.3).
conclusionsClinical outcomes and costs for children hospitalized with CAP are not different when treatment is with narrow- compared with broad-spectrum therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.