ArticlePediatrics2013
Influenza-associated pediatric deaths in the United States, 2004-2012.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- [Efficacy and safety of pediatric flu vaccination: a systematic review].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Pooled it
- Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.American journal of epidemiology · 2018Pooled it
- Immunogenicity and Safety of an MF59-adjuvanted Quadrivalent Seasonal Influenza Vaccine in Young Children at High Risk of Influenza-associated Complications: A Phase III, Randomized, Observer-blind, Multicenter Clinical Trial.The Pediatric infectious disease journal · 2020Trial
- Influenza vaccination in children primed with MF59-adjuvanted or non-adjuvanted seasonal influenza vaccine.Human vaccines & immunotherapeutics · 2015Trial
- Clinical impact of baloxavir-induced PA I38T/M substitutions in diverse influenza populations: a systematic review and meta-analysis.Virus research · 2026Article
- Development and validation of a cytokine-associated nomogram for predicting severe influenza A virus infection in children.Virus genes · 2026Article
- Review
- Pathogenesis of MRSA-influenza co-infection: implications for ECMO therapeutic strategies - a mini-review.Frontiers in immunology · 2026Review
- Congenital Heart Defects and Concurrent Diagnoses in Influenza Hospitalization in the Pediatric Health Information System Study, 2004-2019.Pediatric cardiology · 2025Article
- Retrospective Epidemiological Analysis of Influenza A Infections in a Single Hospital in Korea (2007-2024): Age, Sex, and Seasonal Patterns.Pathogens (Basel, Switzerland) · 2025Article
- Mathematical Model of Influenza Infection Suggests JAK-STAT Activity Drives Severe Pathologies in Juvenile Mice.Frontiers in applied mathematics and statistics · 2025Article
- Estimated Vaccine Effectiveness for Pediatric Patients With Severe Influenza, 2015-2020.JAMA network open · 2024Article
- Identification of neurological complications in childhood influenza: a random forest model.BMC pediatrics · 2024Article
- Severe Influenza Virus and Respiratory Syncytial Virus Infections in Intensive Care Over the Last 15 Years.Cureus · 2023Article
- Memory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children.NPJ vaccines · 2023Article
- Knowledge, Attitudes, and Practices of Influenza Vaccination among Parents of Children with Asthma: A Cross-Sectional Study.Vaccines · 2023Article
- Impact of coinfection status and comorbidity on disease severity in adult emergency department patients with influenza B.Influenza and other respiratory viruses · 2022Article
- Evaluation of immunization status in patients with cerebral palsy: a multicenter CP-VACC study.European journal of pediatrics · 2022Article
- Review
- Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series.EClinicalMedicine · 2021Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
backgroundInfluenza-associated deaths in children occur annually. We describe the epidemiology of influenza-associated pediatric deaths from the 2004-2005 through the 2011-2012 influenza seasons.
methodsDeaths in children <18 years of age with laboratory-confirmed influenza virus infection were reported to the Centers for Disease Control and Prevention by using a standard case report form to collect data on demographic characteristics, medical conditions, clinical course, and laboratory results. Characteristics of children with no high-risk medical conditions were compared with those of children with high-risk medical conditions.
resultsFrom October 2004 through September 2012, 830 pediatric influenza-associated deaths were reported. The median age was 7 years (interquartile range: 1-12 years). Thirty-five percent of children died before hospital admission. Of 794 children with a known medical history, 43% had no high-risk medical conditions, 33% had neurologic disorders, and 12% had genetic or chromosomal disorders. Children without high-risk medical conditions were more likely to die before hospital admission (relative risk: 1.9; 95% confidence interval: 1.6-2.4) and within 3 days of symptom onset (relative risk: 1.6; 95% confidence interval: 1.3-2.0) than those with high-risk medical conditions.
conclusionsInfluenza can be fatal in children with and without high-risk medical conditions. These findings highlight the importance of recommendations that all children should receive annual influenza vaccination to prevent influenza, and children who are hospitalized, who have severe illness, or who are at high risk of complications (age <2 years or with medical conditions) should receive antiviral treatment as early as possible.
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