ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2014
Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Meta-analysis Integrated With Multi-omics Data Analysis to Elucidate Pathogenic Mechanisms of Age-Related Knee Osteoarthritis in Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Pooled it
- Experimental models of osteoarthritis: Advances, limitations and rational selection for translational research.Journal of orthopaedic translation · 2026Review
- Joint damage is more severe following a single bout than multiple bouts of high magnitude loading in mice.Osteoarthritis and cartilage · 2026Article
- A high throughput cell stretch device for investigating mechanobiologyAPL bioengineering · 2024Article
- Review
- Small-Animal Compression Models of Osteoarthritis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Regenerative Engineering Animal Models for Knee Osteoarthritis.Regenerative engineering and translational medicine · 2022Article
- Comparison of early outcomes of arthroscopic labral repair or debridement : a study using the UK Non-Arthroplasty Hip Registry dataset.Bone & joint open · 2022Article
- Article
- Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Characterization of Post-Traumatic Osteoarthritis in Rats Following Anterior Cruciate Ligament Rupture by Non-Invasive Knee Injury (NIKI).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing.British journal of pharmacology · 2019Article
- Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.Bone research · 2019Article
- Pros and cons of mouse models for studying osteoarthritis.Clinical and translational medicine · 2018Review
- Article
- Comparison of knee injury threshold during tibial compression based on limb orientation in mice.Journal of biomechanics · 2018Article
- Osteophyte formation after ACL rupture in mice is associated with joint restabilization and loss of range of motion.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Osteoarthritis: Pathology, Mouse Models, and Nanoparticle Injectable Systems for Targeted Treatment.Annals of biomedical engineering · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Joint instability and cartilage trauma have been previously studied and identified as key mediators in the development of posttraumatic osteoarthritis (PTOA). The purpose of this study was to use an in vivo model to compare the effect of joint instability, caused by the rupture of the anterior cruciate ligament (ACL), versus cartilage compression. In this study, mice were subjected to cyclical axial loads of twelve Newtons (N) for 240 cycles or until the ACL ruptured. One and eight weeks after this procedure, knees were sectioned coronally and evaluated for osteoarthritis by histology. Using a scoring scale established by [Pritzker K, Gay S, Jimenez S, et al. (2006): Osteoarthritis Cartilage 14:13-29], the articular cartilage across each surface was scored and combined to produce a total degeneration score. The ACL-ruptured group had a significantly greater total degeneration score than either control or compression treated joints at 1 and 8 weeks. Additionally, only sections from ACL-ruptured knees consistently showed synovitis after 1 week and osteophyte formation after 8 weeks. Thus, it appears using that ACL rupture consistently creates a severe osteoarthritis phenotype, while axial cartilage compression alone does not appear to be an appropriate method of inducing PTOA in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.