ArticleDigestive diseases and sciences2014
High serum vaspin concentrations in patients with ulcerative colitis.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Mesenteric adipose tissue: from protective gatekeeper to driver of inflammatory bowel disease.Immunometabolism (Cobham, Surrey) · 2026Review
- The role of serum vaspin level in the early diagnosis of mesenteric ischemia induced in experimental animal model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- The role of the novel adipokines vaspin and omentin in chronic inflammatory diseases.Pediatric endocrinology, diabetes, and metabolism · 2023Review
- Impact of Obesity on the Course of Management of Inflammatory Bowel Disease-A Review.Nutrients · 2022Review
- Investigating the role of heat shock protein 47 in fibrosis in Crohn's disease.Scientific reports · 2022Article
- The correlation of serum Vaspin, S100A12 and PCT levels with the severity of ulcerative colitis and its clinical significance.American journal of translational research · 2021Article
- Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases.Biomolecules · 2019Review
- Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Clinical Utility of Biomarkers in IBD.Current gastroenterology reports · 2015Review
- Obesity, inflammation, and lung injury (OILI): the good.Mediators of inflammation · 2014Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipocytokines are associated with energy homeostasis and mediate various immune responses and inflammatory processes. Vaspin is a novel adipocytokine that is thought to exhibit anti-inflammatory effects.
aimWe aimed to evaluate serum vaspin levels in inflammatory bowel disease (IBD) and determine its possible associations with the course and to clarify its intestinal localization.
methodsSerum samples were obtained from patients with Crohn's disease (CD; n = 30) and ulcerative colitis (UC; n = 33) and from healthy volunteers (controls; n = 26). Enzyme-linked immunosorbent assays were performed for all patients. Vaspin immunohistochemical staining was performed for intestines affected with IBD.
resultsSerum vaspin concentrations were significantly higher in patients with UC than in patients with CD and controls (422.9 ± 361.9 vs. 163.4 ± 116.2 vs. 147.5 ± 89.4 pg/mL, respectively; P < 0.01). There was no difference in the serum vaspin concentrations between the patients with CD and controls. There was also no difference in the serum vaspin concentrations between the patients with active IBD and those with inactive IBD. However, the serum vaspin concentrations of most patients with UC increased after remission induction. Vaspin was expressed in the adipocytes of the mesenteric adipose tissues but not in the epithelial or inflammatory cells of large intestines of the patients with IBD.
conclusionsSerum vaspin concentrations are elevated in patients with UC and increase further after remission induction, suggesting that vaspin may aid the auxiliary diagnosis of UC and may be useful for assessing disease activity in patients.
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