ArticleJournal of neuro-oncology2014
Gross total resection improves overall survival in children with choroid plexus carcinoma.
Article in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Leptomeningeal Dissemination in Choroid Plexus Tumors: Magnetic Resonance Imaging Appearance and Risk Factors.Children (Basel, Switzerland) · 2025Article
- Molecular heterogeneity of pediatric choroid plexus carcinomas determines the distinctions in clinical course and prognosis.Neuro-oncology · 2023Article
- Preclinical validation of a novel therapeutic strategy for choroid plexus carcinoma.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Enhancing the Reliability of Intraoperative Ultrasound in Pediatric Space-Occupying Brain Lesions.Diagnostics (Basel, Switzerland) · 2023Article
- Primary adult choroid plexus carcinomas: a single-center experience with a systematic review.Frontiers in oncology · 2023Article
- Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog.Veterinary sciences · 2022Article
- Intraventricular choroid plexus tumors: clinical characteristics and impact of current management on survival.Journal of neuro-oncology · 2020Article
- Near-Infrared Fluorescent Rosol Dye Tailored toward Lymphatic Mapping Applications.Analytical chemistry · 2019Article
- Successful multimodal treatment of a gigantic choroid plexus carcinoma (CPC) in an 8-year-old girl.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Successful Treatment of Recurrent Li-Fraumeni Syndrome-related Choroid Plexus Carcinoma.Journal of pediatric hematology/oncology · 2017Article
- A French retrospective study on clinical outcome in 102 choroid plexus tumors in children.Journal of neuro-oncology · 2017Article
- Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database.Journal of neuro-oncology · 2015Article
- A typical radiological presentation in a case of choroid plexus carcinoma.Surgical neurology international · 2014Article
- Resection of Pediatric Brain Tumors: Intraoperative Ultrasound Revisited.Journal of pediatric neurosciencesArticle
- Outcome and molecular analysis of young children with choroid plexus carcinoma treated with non-myeloablative therapy: results from the SJYC07 trial.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Choroid plexus carcinoma (CPC) is a rare, malignant, primary brain tumor with a poor prognosis. While previous reports have shown benefits of aggressive surgery, very few large-scale studies have focused exclusively on the pediatric population, for whom the risks of aggressive surgery must be weighed carefully against the benefits. We performed a comprehensive systematic review of pediatric CPCs to test the effects of gross total resection (GTR) on overall survival (OS) and progression-free survival (PFS). A Pubmed search was performed to identify children with CPC who underwent surgical resection. Only disaggregated clinical cases in which extent of resection was confirmed by CT or MRI were included for analysis. Kaplan-Meier and multivariate Cox regression survival analyses were performed to determine the effects of extent of resection on OS and PFS. Disaggregated clinical data from a total of 102 pediatric CPC patients (age ≤18 years) with known extent of resection and overall survival were analyzed. GTR was significantly associated with better OS by Kaplan-Meier analysis (logrank p < 0.001). Multivariate Cox regression analysis adjusting for age, gender, tumor location (supratentorial vs. infratentorial), and type of adjuvant therapy (chemotherapy, radiation, and combined therapy), showed that GTR independently increased OS (p = 0.006). While GTR also improved PFS on Kaplan-Meier analysis (p = 0.027), the effect did not meet our criteria for significance in our multivariate Cox model (p = 0.120). GTR improved OS of pediatric CPC and is recommended if it can be safely performed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.