ArticleClinical cardiology2013
Predictors of long-term adherence to evidence-based cardiovascular disease medications in outpatients with stable atherothrombotic disease: findings from the REACH Registry.
Article in Clinical cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- The burden of non-adherence to cardiovascular medications among the aging population in Australia: a meta-analysis.Drugs & aging · 2015Pooled it
- The Burden of Structured Self-Monitoring of Blood Glucose on Diabetes-Specific Quality of Life and Locus of Control in Patients with Noninsulin-Treated Type 2 Diabetes: The PRISMA Study.Diabetes technology & therapeutics · 2016Trial
- Can phone-based motivational interviewing improve medication adherence to antiplatelet medications after a coronary stent among racial minorities? A randomized trial.Journal of general internal medicine · 2015Trial
- Medication non-adherence after myocardial infarction: an exploration of modifying factors.Journal of general internal medicine · 2015Trial
- Population-Level Gaps in Coronary Artery Disease Care: A Focused Review.Methodist DeBakey cardiovascular journal · 2025Review
- Two-Year Follow-Up of Chronic Ischemic Heart Disease Patients in a Specialized Center in Brazil.Arquivos brasileiros de cardiologia · 2023Article
- Healthcare Resources Utilization throughout the Last Year of Life after Acute Myocardial Infarction.Journal of clinical medicine · 2023Article
- [Control of arterial hypertension: a pending issueControle da hipertensão arterial: um assunto inacabado].Revista panamericana de salud publica = Pan American journal of public health · 2022Article
- Health Facts Medication Adherence in Transplantation (H-MAT) Study: A Secondary Analysis of Determinants and Outcomes of Medication Nonadherence in Adult Kidney Transplant Recipients.International journal of nephrology · 2022Article
- Immigrants, Ethnicity, and Adherence to Secondary Cardiac Prevention Therapy: A Substudy of the ISLAND Trial.CJC open · 2021Article
- Risk factor control across the spectrum of cardiovascular risk: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).American journal of preventive cardiology · 2021Article
- Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials: Insights From the TIMI trials.Circulation · 2021Article
- Changing Patterns of Medical Visits and Factors Associated with No-show in Patients with Rheumatoid Arthritis during COVID-19 Pandemic.Journal of Korean medical science · 2020Observational
- Associations between Subsequent Hospitalizations and Primary Ambulatory Services Utilization within the First Year after Acute Myocardial Infarction and Long-Term Mortality.Journal of clinical medicine · 2020Article
- Tackling Elevated Risk in PAD: Focus on Antithrombotic and Lipid Therapy for PAD.Current cardiology reports · 2020Review
- Long-Term Survival after Acute Myocardial Infarction in Lithuania during Transitional Period (1996-2015): Data from Population-Based Kaunas Ischemic Heart Disease Register.Medicina (Kaunas, Lithuania) · 2019Article
- Cost-Effectiveness of Aspirin Adherence for Secondary Prevention of Cardiovascular Events.PharmacoEconomics - open · 2018Article
- Medication Adherence and its Related Factors in Patients Undergoing Coronary Artery Angioplasty.Journal of caring sciences · 2018Article
- Challenges and Opportunities to Scale Up Cardiovascular Disease Secondary Prevention in Latin America and the Caribbean.Global heart · 2018Review
- Polypill: an affordable strategy for cardiovascular disease prevention in low-medium-income countries.Therapeutic advances in cardiovascular disease · 2018Review
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite overall improvements in cardiovascular-disease therapies and outcomes, medication nonadherence remains an important barrier to effective secondary prevention of atherothrombotic disease. HYPOTHESIS: Long-term medication adherence in outpatients with stable atherothrombotic disease is impacted by demographic and clinical factors.
methodsWe examined data from the prospective international Reduction of Atherothrombosis for Continued Health (REACH) Registry. Analyses were derived from 25 737 patients with established atherothrombotic disease with complete adherence data at enrollment and at year 4. Adherence was defined as patients' self-report of taking medications based on class I American College of Cardiology/American Heart Association guidelines for secondary prevention as defined, including antiplatelet agents, statins, and antihypertensive medications.
resultsAmong patients with atherothrombotic disease, 12 500 (48.6%) were deemed adherent to guideline-recommended medications. Adherent patients were younger, white, and had less polyvascular disease. Hispanic and East Asian patients were less likely to be adherent as compared with white patients (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.59-0.88; and OR: 0.67, 95% CI: 0.53-0.83, respectively). Patients who had a nonfatal MI or underwent coronary angioplasty/stenting during follow-up were more likely to be adherent compared with patients without these events (OR: 1.73, 95% CI: 1.25-2.38; and OR: 2.15, 95% CI: 1.72-2.67, respectively). On the other hand, nonfatal stroke during follow-up was inversely associated with adherence (OR: 0.77, 95% CI: 0.61-0.97).
conclusionsUsing a large international registry of outpatients with atherothrombotic disease, we found that age, region, race/ethnicity, and incident cardiovascular events were predictive of long-term guideline adherence for secondary prevention, suggesting that certain patient groups may benefit from targeted interventions to improve adherence.
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