Evidence map›Paper›PMID 24166382›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2014

Noninvasive in vivo monitoring of extracellular vesicles.

Charles P Lai, Bakhos A Tannous, Xandra O Breakefield

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. 80 years of extracellular vesicles: from discovery to clinical translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Research progress inExtracellular vesicles and circulating nucleic acids · 2023
    Review
  7. Article
  8. Stem Cell Therapy in Treating Epilepsy.Frontiers in neuroscience · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Facile metabolic glycan labeling strategy for exosome tracking.Biochimica et biophysica acta. General subjects · 2018
    Article
  20. Shedding light on the cell biology of extracellular vesicles.Nature reviews. Molecular cell biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Charles P LaiDepartment of Neurology, Neuroscience Center, Massachusetts General Hospital, Boston, MA, USA.
Bakhos A Tannous
Xandra O Breakefield
Harvard University · USMassachusetts General Hospital · US

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
Interdepartmental Neuroscience CenterP30NS045776 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, TANNOUS, BAKHOS A · 2003 to 2018
$11.1M
Tumor exosomes as agents of genetic changeR01CA141150 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS · 2009 to 2011
$873k
CIHRNCI NIH HHS CA141150NCI NIH HHS P01 CA069246NCI NIH HHS R01 CA141150NINDS NIH HHS P30 NS045776
6 · The paper itself

Abstract

Extracellular vesicles (EVs) including exosomes and microvesicles are nanometer-sized vesicles released by cells to deliver lipids, cellular proteins, mRNAs, and noncoding RNAs, thereby facilitating intercellular communication without direct cell-to-cell contacts. Due to their nanoscale size, EVs have been visualized under microscopy in vitro. We here describe a strategy to label EVs with Gaussia luciferase for noninvasive bioluminescence imaging and monitoring of systemically administered EVs in vivo.

Indexed as

Luminescent MeasurementsAnimalsCell FractionationCopepodaHEK293 CellsHumansLuciferasesMiceMolecular ImagingTransport VesiclesLuciferases

Identifiers

PMID24166382
PMCPMC5798617
OpenAlexW2312596227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.