ArticleDrug safety2013
Empirical performance of the case-control method: lessons for developing a risk identification and analysis system.
Article in Drug safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Methods for drug safety signal detection using routinely collected observational electronic health care data: A systematic review.Pharmacoepidemiology and drug safety · 2023Pooled it
- Pooled it
- Pooled it
- Foundational model aided automatic high-throughput drug screening using self-controlled cohort study.medRxiv : the preprint server for health sciences · 2024Article
- The State of Use and Utility of Negative Controls in Pharmacoepidemiologic Studies.American journal of epidemiology · 2024Review
- Randomized and non-randomized designs for causal inference with longitudinal data in rare disorders.Orphanet journal of rare diseases · 2021Review
- Treatment with TNF-α inhibitors versus methotrexate and the association with dementia and Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Adverse Drug Reaction Discovery from Electronic Health Records with Deep Neural Networks.Proceedings of the ACM Conference on Health, Inference, and Learning · 2020Article
- How Confident Are We about Observational Findings in Healthcare: A Benchmark Study.Harvard data science review · 2020Article
- A plea to stop using the case-control design in retrospective database studies.Statistics in medicine · 2019Article
- Pharmacovigilance via Baseline Regularization with Large-Scale Longitudinal Observational Data.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2017Article
- A Multiagent System for Integrated Detection of Pharmacovigilance Signals.Journal of medical systems · 2016Article
- Article
- Computational approaches for pharmacovigilance signal detection: toward integrated and semantically-enriched frameworks.Drug safety · 2015Article
- Fidelity assessment of a clinical practice research datalink conversion to the OMOP common data model.Drug safety · 2014Article
- Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest.Drug safety · 2014Article
- Variation in choice of study design: findings from the Epidemiology Design Decision Inventory and Evaluation (EDDIE) survey.Drug safety · 2013Article
- Evaluating performance of risk identification methods through a large-scale simulation of observational data.Drug safety · 2013Article
- A comparison of the empirical performance of methods for a risk identification system.Drug safety · 2013Article
- Replication of the OMOP experiment in Europe: evaluating methods for risk identification in electronic health record databases.Drug safety · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsiderable attention now focuses on the use of large-scale observational healthcare data for understanding drug safety. In this context, analysts utilize a variety of statistical and epidemiological approaches such as case-control, cohort, and self-controlled methods. The operating characteristics of these methods are poorly understood.
objectiveEstablish the operating characteristics of the case-control method for large scale observational analysis in drug safety. RESEARCH
designWe empirically evaluated the case-control approach in 5 real observational healthcare databases and 6 simulated datasets. We retrospectively studied the predictive accuracy of the method when applied to a collection of 165 positive controls and 234 negative controls across 4 outcomes: acute liver injury, acute myocardial infarction, acute kidney injury, and upper gastrointestinal bleeding.
resultsIn our experiment, the case-control method provided weak discrimination between positive and negative controls. Furthermore, the method yielded positively biased estimates and confidence intervals that had poor coverage properties.
conclusionsFor the four outcomes we examined, the case-control method may not be the method of choice for estimating potentially harmful effects of drugs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.