ReviewJournal of applied toxicology : JAT2014
New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis.
Review in Journal of applied toxicology : JAT, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations.Toxicological sciences : an official journal of the Society of Toxicology · 2024Pooled it
- Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens.Archives of toxicology · 2020Guideline
- An updated systematic review on the possible effect of nonylphenol on male fertility.Environmental science and pollution research international · 2017Pooled it
- The use of cultured human hepatocytes as a test system to evaluate cell proliferation as a key event in nongenotoxic carcinogenesis.Archives of toxicology · 2026Article
- A Method to Calibrate Chemical-Agnostic Quantitative Adverse Outcome Pathways on Multiple Chemical Data.Chemical research in toxicology · 2026Article
- Reviewing the thoroughness of human safety testing for succinate dehydrogenase inhibitors: fluopyram as a case study.Archives of toxicology · 2026Review
- Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data.Current research in toxicology · 2026Article
- Systematic evaluation of the evidence base on ethylCurrent research in toxicology · 2026Review
- An evaluation of the human relevance of the thyroid follicular cell tumors observed in rats treated with the synthetic fungicide, pyridachlometyl, based on mode of action.Archives of toxicology · 2025Article
- An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action.Archives of toxicology · 2025Article
- A proposal of criteria to support the EU classification on endocrine disruption for the thyroid modality and their application to four data-rich case studies.Archives of toxicology · 2025Article
- Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies.Frontiers in toxicology · 2025Article
- Systematic evaluation of the evidence base on methylCurrent research in toxicology · 2025Review
- Risks to human and animal health from the presence of bromide in food and feed.EFSA journal. European Food Safety Authority · 2025Article
- Adverse Outcome Pathways Mechanistically Describing Hepatotoxicity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- E-waste: mechanisms of toxicity and safety testing.FEBS open bio · 2024Review
- Associations between Ethylene Oxide Exposure and Liver Function in the US Adult Population.Toxics · 2024Article
- Specific effects on the thyroid relevant for performing a dietary cumulative risk assessment of pesticide residues: 2024 update.EFSA journal. European Food Safety Authority · 2024Article
- Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice.Critical reviews in toxicology · 2024Review
- An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis.Chemical research in toxicology · 2023Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The World Health Organization/International Programme on Chemical Safety mode of action/human relevance framework has been updated to reflect the experience acquired in its application and extend its utility to emerging areas in toxicity testing and non-testing methods. The underlying principles have not changed, but the framework's scope has been extended to enable integration of information at different levels of biological organization and reflect evolving experience in a much broader range of potential applications. Mode of action/species concordance analysis can also inform hypothesis-based data generation and research priorities in support of risk assessment. The modified framework is incorporated within a roadmap, with feedback loops encouraging continuous refinement of fit-for-purpose testing strategies and risk assessment. Important in this construct is consideration of dose-response relationships and species concordance analysis in weight of evidence. The modified Bradford Hill considerations have been updated and additionally articulated to reflect increasing experience in application for cases where the toxicological outcome of chemical exposure is known. The modified framework can be used as originally intended, where the toxicological effects of chemical exposure are known, or in hypothesizing effects resulting from chemical exposure, using information on putative key events in established modes of action from appropriate in vitro or in silico systems and other lines of evidence. This modified mode of action framework and accompanying roadmap and case examples are expected to contribute to improving transparency in explicitly addressing weight of evidence considerations in mode of action/species concordance analysis based on both conventional data sources and evolving methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.