ArticleThe American journal of tropical medicine and hygiene2013
Scrub typhus meningitis or meningoencephalitis.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02339259 (Rickettsial Disease in Febrile Hospitalised Patients in a Tertiary Referral Hospital in Bangladesh), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rickettsial Disease in Febrile Hospitalised Patients in a Tertiary Referral Hospital in Bangladesh
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality.PLoS neglected tropical diseases · 2022Pooled it
- Clinical Profile and Long-Term Outcomes of Scrub Typhus Meningoencephalitis in Children.Cureus · 2025Article
- Article
- Risk factors of thromboembolic events in patients with scrub typhus.PLoS neglected tropical diseases · 2024Article
- Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report.Experimental and therapeutic medicine · 2024Article
- Association of Scrub Typhus in Children with Acute Encephalitis Syndrome and Meningoencephalitis, Southern India.Emerging infectious diseases · 2023Review
- Scrub typhus in rural areas & suburbs of Vidarbha region of Maharashtra.The Indian journal of medical research · 2020Article
- Meningitis due to scrub typhus: the importance of a differential diagnosis in an endemic area.BMJ case reports · 2018Article
- Central Nervous System Infection Associated withThe American journal of tropical medicine and hygiene · 2017Article
- A Case of Scrub Typhus Related Encephalopathy Presenting as Rapidly Progressive Dementia.Dementia and neurocognitive disorders · 2017Article
- Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice.PLoS neglected tropical diseases · 2017Article
- Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection.PLoS neglected tropical diseases · 2017Article
- Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings.The American journal of tropical medicine and hygiene · 2017Article
- Spontaneous Splenic Rupture Caused by Scrub Typhus.The American journal of tropical medicine and hygiene · 2016Article
- Scrub Typhus in Northeastern Thailand: Eschar Distribution, Abnormal Electrocardiographic Findings, and Predictors of Fatal Outcome.The American journal of tropical medicine and hygiene · 2016Article
- Epidemic characteristics and spatio-temporal patterns of scrub typhus during 2006-2013 in Tai'an, Northern China.Epidemiology and infection · 2015Article
- Blood-Brain Barrier Function and Biomarkers of Central Nervous System Injury in Rickettsial Versus Other Neurological Infections in Laos.The American journal of tropical medicine and hygiene · 2015Article
- Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.The Lancet. Global health · 2015Article
- Dissemination of Orientia tsutsugamushi and inflammatory responses in a murine model of scrub typhus.PLoS neglected tropical diseases · 2014Article
- Tsutsugamushi Disease (Scrub Typhus) Meningoencephalitis in North Eastern India: A Prospective Study.Annals of medical and health sciences researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orientia tsutsugamushi induces vasculitis leading to symptoms of systemic organ invasion including meningitis and meningoencephalitis. We conducted a retrospective case-control study of scrub typhus patients to investigate the clinical and laboratory features of patients with scrub typhus meningitis or meningoencephalitis, and the therapeutic outcomes, and to determine the predictor factors. Cases were 22 patients with scrub typhus meningitis or meningoencephalitis, and controls were 303 patients without meningitis or meningoencephalitis. Multivariate analysis showed that the presence of pneumonitis was associated with the occurrence of scrub typhus meningitis and meningoencephalitis (odds ratio [OR] 8.9; P < 0.001; confidence interval [CI] 2.9-27.2). Although appropriate antimicrobials such as doxycycline agents were administered at an early stage, meningitis or meningoencephalitis still occurred in some cases. Physicians should be aware that meningitis or meningoencephalitis may develop during appropriate drug therapy such as doxycycline. Close observation and great care are essential for patients with risk factors, particularly pneumonitis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.