ArticleCell research2013
Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13.
Article in Cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 100 citations in OpenAlex.
- TaPP2C-a5 fine-tunes wheat seed dormancy and germination with a Triticeae-specific, alternatively spliced transcript.Journal of advanced research · 2026Article
- The ADF4-RCAR12 module regulates ABA-mediated drought tolerance inFrontiers in plant science · 2026Article
- Article
- ABA-independent PP2C-binding in PYLs traces to bacterial origins and persists in land plants.Nature communications · 2025Article
- Integrative multi-omics analysis unravels chitosan-mediated delay of mango fruit ripening through hormonal and metabolic reprogramming.Food chemistry. Molecular sciences · 2025Article
- Characterization of the ABA receptor PYL gene family and identification of DoPYL1-interacting proteins in Dendrobium officinale.BMC plant biology · 2025Article
- High-Throughput Fluorescence Screening Enables Globally Consistent Identification of ABA Signaling Modulators.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Identification ofForestry research · 2025Article
- Osmotic signaling releases PP2C-mediated inhibition of Arabidopsis SnRK2s via the receptor-like cytoplasmic kinase BIK1.The EMBO journal · 2024Article
- Physiological and Transcriptome Analyses Reveal the Protective Effect of Exogenous Trehalose in Response to Heat Stress in Tea Plant (Plants (Basel, Switzerland) · 2024Article
- Structural and functional characterization of genes PYL-PP2C-SnRK2s in the ABA signalling pathway of Cucurbita pepo.BMC genomics · 2024Article
- Unveiling the crucial roles of abscisic acid in plant physiology: implications for enhancing stress tolerance and productivity.Frontiers in plant science · 2024Review
- Reconstitution of phytochrome A-mediated light modulation of the ABA signaling pathways in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genome-wide identification of the PYL gene family of tea plants (Camellia sinensis) revealed its expression profiles under different stress and tissues.BMC genomics · 2023Article
- GhPYL9-5D and GhPYR1-3 A positively regulate Arabidopsis and cotton responses to ABA, drought, high salinity and osmotic stress.BMC plant biology · 2023Article
- A Potential ABA Analog to Increase Drought Tolerance inInternational journal of molecular sciences · 2023Article
- Core Components of Abscisic Acid Signaling and Their Post-translational Modification.Frontiers in plant science · 2022Review
- Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure.Nature communications · 2021Article
- Influence of virus-host interactions on plant response to abiotic stress.Plant cell reports · 2021Review
- The Multifaceted Regulation of SnRK2 Kinases.Cells · 2021Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
PYR1/PYL/RCAR family proteins (PYLs) are well-characterized abscisic acid (ABA) receptors. Among the 14 PYL members in Arabidopsis thaliana, PYL13 is ABA irresponsive and its function has remained elusive. Here, we show that PYL13 selectively inhibits the phosphatase activity of PP2CA independent of ABA. The crystal structure of PYL13-PP2CA complex, which was determined at 2.4 Å resolution, elucidates the molecular basis for the specific recognition between PP2CA and PYL13. In addition to the canonical interactions between PYLs and PP2Cs, an extra interface is identified involving an element in the vicinity of a previously uncharacterized CCCH zinc-finger (ZF) motif in PP2CA. Sequence blast identified another 56 ZF-containing PP2Cs, all of which are from plants. The structure also reveals the molecular determinants for the ABA irresponsiveness of PYL13. Finally, biochemical analysis suggests that PYL13 may hetero-oligomerize with PYL10. These two PYLs antagonize each other in their respective ABA-independent inhibitions of PP2Cs. The biochemical and structural studies provide important insights into the function of PYL13 in the stress response of plant and set up a foundation for future biotechnological applications of PYL13.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.