ArticleScientific reports2013
Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Progress and challenges in the development of advanced pancreatic cancer organoids.Journal of experimental & clinical cancer research : CR · 2026Review
- G-quadruplexes in MTOR and induction of autophagy.Scientific reports · 2024Article
- Article
- Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression.Antioxidants (Basel, Switzerland) · 2022Article
- Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex.PloS one · 2022Article
- Sugar modulation of anaerobic-response networks in maize root tips.Plant physiology · 2021Article
- The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression.Cell death & disease · 2020Article
- The hTERT core promoter forms three parallel G-quadruplexes.Nucleic acids research · 2020Article
- A topological transition from bimolecular quadruplex to G-triplex/tri-G-quadruplex exhibited by truncated double repeats of human telomere.European biophysics journal : EBJ · 2018Article
- Whole-Transcriptome Profiling of Canine and Human in Vitro Models Exposed to a G-Quadruplex Binding Small Molecule.Scientific reports · 2018Article
- Identification and characterization of G-quadruplex formation within the EP0 promoter of pseudorabies virus.Scientific reports · 2018Article
- Endogenous HIF2A reporter systems for high-throughput functional screening.Scientific reports · 2018Article
- Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.Nature communications · 2016Article
- Directly lighting up RNA G-quadruplexes from test tubes to living human cells.Nucleic acids research · 2015Article
- KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.Scientific reports · 2015Article
- Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation.RNA biology · 2015Article
- Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes.Scientific reports · 2014Article
- Hypoxia regulates CD9-mediated keratinocyte migration via the P38/MAPK pathway.Scientific reports · 2014Article
- 2'-Epi-uscharin from the latex of Calotropis gigantea with HIF-1 inhibitory activity.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The hypoxia-inducible transcription factor (HIF) co-ordinates the response of tumours to low oxygen by stimulating genes involved in metabolism and angiogenesis. HIF pathway activation is associated with decreased progression-free survival and increased mortality; compounds that target this pathway are potential agents for the treatment of a range of solid tumour malignancies. Renal cancers are likely to be particularly sensitive to inhibition of the HIF pathway since ~80% show constitutive activation of HIF. We have previously described the di-substituted naphthalene derivative, CL67, which binds to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro. We show here that CL67 blocks HIF expression leading to inhibition of HIF-transactivation and down-regulation of downstream target genes and proteins in renal carcinoma cell lines and in a mouse xenograft model of renal cancer. This inhibition is independent of pathways that control HIF abundance through oxygen-dependant degradation and oxygen dependant HIF sub-unit expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.