Evidence map›Paper›PMID 24165728›Full record

ArticleNature genetics2013

No pain, more gain.

James J Cox, John N Wood

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genetic pain loss disorders.Nature reviews. Disease primers · 2022
    Review
  2. Article
  3. Review
  4. Editors' Pick: What a pain…, or not!Investigative genetics · 2014
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

James J CoxMolecular Nociception Group at the Wolfson Institute for Biomedical Research, University College London, London, UK.
John N Wood

Funding

Biotechnology and Biological Sciences Research Council BB/F000227/1Medical Research Council G0901905Medical Research Council G1100340
6 · The paper itself

Abstract

A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to pain. This finding provides fresh insights into human pain perception and suggests a new avenue for the development of analgesic drugs.

Indexed as

AnimalsHumansNAV1.9 Voltage-Gated Sodium ChannelPainPain PerceptionNAV1.9 Voltage-Gated Sodium ChannelSCN11A protein, human

Identifiers

PMID24165728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.