ArticleThe EMBO journal1985
Complete sequence of a bovine type I cytokeratin gene: conserved and variable intron positions in genes of polypeptides of the same cytokeratin subfamily.
Article in The EMBO journal, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 51 citations in OpenAlex.
- Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.The EMBO journal · 1993Article
- The bovine genome map.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Review
- Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Epidermal differentiation: the bare essentials.The Journal of cell biology · 1990Review
- Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.Molecular and cellular biology · 1989Article
- The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA.Nucleic acids research · 1989Article
- Enhancer elements directing cell-type-specific expression of cytokeratin genes and changes of the epithelial cytoskeleton by transfections of hybrid cytokeratin genes.The EMBO journal · 1989Article
- A novel nucleoskeletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae.The EMBO journal · 1988Article
- Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.The Journal of cell biology · 1988Article
- Concerted gene duplications in the two keratin gene families.Journal of molecular evolution · 1988Article
- Differentially expressed bovine cytokeratin genes. Analysis of gene linkage and evolutionary conservation of 5'-upstream sequences.The EMBO journal · 1987Article
- Gene organization of the small subunit of human calcium-activated neutral protease.Nucleic acids research · 1986Article
- Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis.The Journal of cell biology · 1986Article
- Cloning of cDNA and amino acid sequence of a cytokeratin expressed in oocytes of Xenopus laevis.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein.The EMBO journal · 1986Article
- Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs.Nucleic acids research · 1986Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The complete sequence of a bovine gene encoding an epidermal cytokeratin of mol. wt. 54 500 (No VIb) of the acidic (type I) subfamily is presented, including an extended 5' upstream region. The gene (4377 bp, seven introns) which codes for a representative of the glycine-rich subtype of cytokeratins of this subfamily, is compared with genes coding for: another subtype of type I cytokeratin; a basic (type II) cytokeratin gene; and vimentin, a representative of another intermediate filament (IF) protein class. The positions of the five introns located within the highly homologous alpha-helix-rich rod domain are identical or equivalent, i.e., within the same triplet, in the two cytokeratin I genes. Four of these intron positions are also identical with intron sites in the vimentin gene, and three of these intron positions are identical or similar in the type I and type II cytokeratin subfamilies. On the other hand, the gene organization of both type I cytokeratins differs from that of the type II cytokeratin in the rod region in five intron positions and in the introns located in the carboxy-terminal tail region, with the exception of one position at the rod-tail junction. Remarkably, the two type I cytokeratins also differ from each other in the positions of two introns located at and in the region coding for the hypervariable, carboxy-terminal portion. The introns and the 5' upstream regions of the cytokeratin VIb gene do not display notable sequence homologies with the other IF protein genes, but sequences identical with--or very similar to--certain viral and immunoglobulin enhancers have been identified.(ABSTRACT TRUNCATED AT 250 WORDS)
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