ArticleMolecules (Basel, Switzerland)2013
Isosakuranetin-5-O-rutinoside: a new flavanone with antidepressant activity isolated from Salvia elegans Vahl.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Effect of Rosifoliol/Agarospirol and 7α-Hydroxysandaracopimaric Acid fromMolecules (Basel, Switzerland) · 2026Article
- Secoisopimaranes from Salvia elegans Vahl leaves as antibacterial agents against Staphylococcus aureus.Scientific reports · 2025Article
- Article
- Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use ofFrontiers in pharmacology · 2024Article
- A Review on the Ethnopharmacology and Phytochemistry of the Neotropical Sages (Frontiers in pharmacology · 2022Review
- Emerging Role of Flavonoids as the Treatment of Depression.Biomolecules · 2021Review
- Antidepressant and anxiolytic compounds isolated from Salvia elegans interact with serotonergic drugs.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- In Vivo Gastroprotective and Antidepressant Effects of Iridoids, Verbascoside and Tenuifloroside fromMolecules (Basel, Switzerland) · 2019Article
- Antidepressant-like Effect of a Chalcone Compound, DHIPC and Its Possible Mechanism.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents.Scientifica · 2018Review
- Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases.CNS drugs · 2017Review
- Antidepressive and antinociceptive effects of ethanolic extract and fruticuline A from Salvia lachnostachys Benth leaves on rodents.PloS one · 2017Article
- Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri.Marine drugs · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
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Registered trials
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