ArticleCNS neuroscience & therapeutics2013
Glia protein aquaporin-4 regulates aversive motivation of spatial memory in Morris water maze.
Article in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Role of Aquaporin-4 in Freezing of Gait and Dynamic Balance Learning in Parkinson's Disease.Scientific reports · 2025Article
- Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury.Experimental brain research · 2024Review
- Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.Journal of clinical medicine · 2021Article
- Value-complexity tradeoff explains mouse navigational learning.PLoS computational biology · 2020Article
- Serum Metabolomics Associating With Circulating MicroRNA Profiles Reveal the Role of miR-383-5p in Rat Hippocampus Under Simulated Microgravity.Frontiers in physiology · 2020Article
- Protection from AmyloidThe Journal of pharmacology and experimental therapeutics · 2019Article
- Isoflurane exposure in infant rats acutely increases aquaporin 4 and does not cause neurocognitive impairment.Bosnian journal of basic medical sciences · 2019Article
- Review
- Physiology of Astroglia.Advances in experimental medicine and biology · 2019Review
- The Glymphatic System in Diabetes-Induced Dementia.Frontiers in neurology · 2018Review
- Physiology of Astroglia.Physiological reviews · 2018Review
- The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory.Frontiers in integrative neuroscience · 2016Review
- Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits.Molecular neurodegeneration · 2015Article
- Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders.CNS neuroscience & therapeutics · 2014Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough extensive investigation has revealed that an astrocyte-specific protein aquaporin-4 (AQP4) participates in regulating synaptic plasticity and memory, a functional relationship between AQP4 and learning processing has not been clearly established. This study was designed to test our hypothesis that AQP4 modulates the aversive motivation in Morris water maze (MWM). METHODS AND
resultsUsing hidden platform training, we observed that AQP4 KO mice significantly decreased their swimming velocity compared with wild-type (WT) mice. To test for a relationship between velocities and escape motivation, we removed the platform and subjected a new group of mice similar to the session of hidden platform training. We found that KO mice exhibited a gradual reduction in swimming velocity, while WT mice did not alter their velocity. In the subsequent probe trial, KO mice after no platform training significantly decreased their mean velocity compared with those KO mice after hide platform training. However, all of KO mice were not impaired in their ability to locate a visible, cued escape platform.
conclusionsOur findings, along with a previous report that AQP4 regulates memory consolidation, implicate a novel role for this glial protein in modulating the aversive motivation in spatial learning paradigm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.