ArticleBMC complementary and alternative medicine2013
Electroacupuncture upregulates ERK signaling pathways and promotes adult hippocampal neural progenitors proliferation in a rat model of depression.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.Frontiers in neuroscience · 2025Review
- Acupuncture may play a key role in anti-depression through various mechanisms in depression.Chinese medicine · 2024Review
- Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson's disease.Journal of traditional and complementary medicine · 2023Article
- Electroacupuncture attenuates LPS-induced depression-like behavior through kynurenine pathway.Frontiers in behavioral neuroscience · 2022Article
- P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease.Chinese medicine · 2021Article
- Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.Neural regeneration research · 2021Review
- The mechanism of electroacupuncture for depression on basic research: a systematic review.Chinese medicine · 2021Review
- The Effects of Electroacupuncture in a Rat Model of Cerebral Ischemia-Reperfusion Injury Following Middle Cerebral Artery Occlusion Involves MicroRNA-223 and the PTEN Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway.Journal of molecular neuroscience : MN · 2018Article
- Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression.Neuroscience bulletin · 2018Article
- Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression.Frontiers in molecular neuroscience · 2018Article
- Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor.Frontiers in psychiatry · 2018Article
- Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors.Journal of neuroinflammation · 2017Article
- Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats.BMC complementary and alternative medicine · 2016Article
- Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERK/ERK and p-P38/P38.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Electroacupuncture promotes proliferation of amplifying neural progenitors and preserves quiescent neural progenitors from apoptosis to alleviate depressive-like and anxiety-like behaviours.Evidence-based complementary and alternative medicine : eCAM · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study, we investigate the proliferation of adult neural stem cells (NSCs) in a chronic unpredictable stress (CUS) rat model of depression, the effects of electroacupunture (EA) on depressive-like symptoms and the corresponding signaling pathways.
methodsSD rats were subjected to 4 weeks of CUS to induce depressive-like behaviors. EA was performed at the Du-20 (Bai-Hui) and GB-34 (Yang-Ling-Quan) acupoints. Rats were injected with BrdU and the brains were cut into sections. Double-labeling with BrdU/Sox2 and p-ERK/Nestin was performed to demonstrate the in vivo proliferation of adult NSCs in hippocampus and ERK activation in NSCs. Hippocampal microdialysates of different groups were collected to observe the in vitro effects on NSCs.
resultsAfter 8 treatments, EA generated a clear antidepressant effect on the stressed rats and promoted the NSC proliferation. ERK activation might be involved in the antidepressant-like effects of EA treatment. Hippocampal microdialysates from EA-treated stressed rats influenced NSCs to form larger neural spheres and exhibit higher p-ERK level in vitro, compared to the untreated stressed rats. Meanwhile, the antidepressant-like effects of EA involved contribution from both acupoint specificity and electrical stimulus.
conclusionsEA might interfere with the hippocampal microenvironment and enhance the activation of ERK signaling pathways. This could mediate, at least in part, the beneficial effects of EA on NSC proliferation and depressive-like behaviors.
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