ArticleAmerican journal of Alzheimer's disease and other dementias2014
Serum trace metal levels in Alzheimer's disease and normal control groups.
Article in American journal of Alzheimer's disease and other dementias, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Brain tissue metal concentrations and Alzheimer's disease neuropathology in total joint arthroplasty patients versus controls.Acta neuropathologica · 2025Article
- Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge.Antioxidants (Basel, Switzerland) · 2024Review
- Metals in Alzheimer's Disease.Biomedicines · 2023Review
- Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data.Journal of applied toxicology : JAT · 2023Review
- Alzheimer's Disease Association with Metals and Metalloids Concentration in Blood and Urine.International journal of environmental research and public health · 2022Article
- Exposure of metal toxicity in Alzheimer's disease: An extensive review.Frontiers in pharmacology · 2022Review
- Metals toxicity and its correlation with the gene expression in Alzheimer's disease.Molecular biology reports · 2021Article
- Effect of environmental toxicants on neuronal functions.Environmental science and pollution research international · 2020Review
- Heavy metal toxicity and the aetiology of glaucoma.Eye (London, England) · 2020Review
- Mercury and Alzheimer's Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization.Biomolecules · 2019Article
- Gut Microbiota Disorder, Gut Epithelial and Blood-Brain Barrier Dysfunctions in Etiopathogenesis of Dementia: Molecular Mechanisms and Signaling Pathways.Neuromolecular medicine · 2019Review
- Insights into the Potential Role of Mercury in Alzheimer's Disease.Journal of molecular neuroscience : MN · 2019Review
- Concentration-dependent effects of mercury and lead on Aβ42: possible implications for Alzheimer's disease.European biophysics journal : EBJ · 2019Article
- Potential Role of Fluoride in the Etiopathogenesis of Alzheimer's Disease.International journal of molecular sciences · 2018Review
- Associations between blood cadmium levels and cognitive function in a cross-sectional study of US adults aged 60 years or older.BMJ open · 2018Article
- Article
- Cadmium and Alzheimer's disease mortality in U.S. adults: Updated evidence with a urinary biomarker and extended follow-up time.Environmental research · 2017Article
- Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.Frontiers in molecular neuroscience · 2017Review
- Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.International journal of molecular sciences · 2016Review
- Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether serum trace metals are related to abnormal cognition in Alzheimer's disease (AD).
methodsWe studied serum lead (Pb), cadmium (Cd), mercury (Hg), and arsenic(As) in 89 patients with AD and in 118 cognitively normal individuals. We analyzed the results of the blood tests and the food intake.
resultsSerum Pb levels correlated with word list recall (P = .039) and word list recognition (P = .037). Without age adjustment, serum Cd levels (P = .044) were significantly higher in the AD group. After stratified age adjustment, the levels of selected trace metals did not differ significantly between AD and normal individuals. Food intakes regarding selected trace metals were not significantly different between the 2 groups.
conclusionsIn this study, serum Pb, Cd, Hg, and As levels were not directly related to abnormal cognition in AD. Serum Pb levels were significantly negatively correlated with verbal memory scores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.