Evidence map›Paper›PMID 24164892›Full record

ArticleBipolar disorders2014

Abnormal screening for gestational diabetes, maternal mood disorder, and preterm birth.

Dorothy Sit, James Luther, John Louis Jesse Dills, Heather Eng, Stephen Wisniewski, Katherine L Wisner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bipolar disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Prevalence and Determinants of Gestational Diabetes Mellitus: A Cross-Sectional Study in China.International journal of environmental research and public health · 2017
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dorothy SitDepartment of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
James Luther
John Louis Jesse Dills
Heather Eng
Stephen Wisniewski
Katherine L Wisner
University of Pittsburgh · USNorthwestern University · US

Funding

Antimanic Use During PregnancyR01MH075921 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WISNER, KATHERINE L · 2006 to 2010
$3.2M
SSRI Rx: Effects on Self Efficacy and Maternal RoleR01MH060335 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WISNER, KATHERINE L. · 1999 to 2004
$2.9M
Efficacy of Bright Light Therapy Vs. Placebo for Bipolar DepressionK23MH082114 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIT, DOROTHY K. · 2009 to 2013
$797k
NIMH NIH HHS K23 MH 082114NIMH NIH HHS K23 MH082114NIMH NIH HHS R01 MH060335NIMH NIH HHS R01 MH 075921NIMH NIH HHS R01 MH075921NIMH NIH HHS R01 MH60335
6 · The paper itself

Abstract

objectiveGestational diabetes mellitus (GDM) affects 7% of pregnant mothers, and those with GDM have increased rates of perinatal complications. Major depressive disorder (MDD) and its pharmacologic treatments are associated with obesity and adverse pregnancy outcomes. In this prospective study, we investigated the relationship between abnormal GDM screens, maternal mood disorders, and adverse outcomes.

methodsWe examined mothers with MDD, those with bipolar disorder (BD), and healthy controls (HC) at 20, 30, and 36 weeks of gestation and delivery. We obtained demographic data and pre-pregnancy body mass index (BMI), and confirmed diagnoses with the Structured Clinical Interview for DSM-IV. We evaluated smoking, alcohol use, substance use, and medication treatments with the Longitudinal Interval Follow-up Evaluation interview. Mothers received the one-hour 50-g glucose challenge test (GCT) at 26-28 weeks of gestation. Outcome variables were preterm birth, birth weight (BW) and peripartum events.

resultsWe enrolled 62 HC, 50 BD, 41 past MDD, and 39 current MDD mother-infant pairs. Mean GCT levels and the frequency of abnormal GCT (>140 mg/dL) did not differ across groups. Rates of smoking (χ(2)  = 20.68, df = 3, p < 0.001), substance use (χ(2)  = 21.76, df = 3, p < 0.001), and pre-pregnancy obesity [BMI ≥ 30 (χ(2)  = 9.97, df = 3, p = 0.019)] differed significantly across groups. Mothers with BD received medications associated with weight gain significantly more often than others [13/45 (29%), p < 0.001). After adjusting for group differences, GCT levels were associated significantly with increased odds for preterm birth (odds ratio = 1.29, 95% confidence interval: 1.0-1.7, p = 0.05) and increased perinatal events (beta = 0.11, p = 0.04) but were not associated with BW.

conclusionsIn mothers with or without mood disorders, having increased GCT levels contributes to a higher likelihood for adverse pregnancy outcomes. Mothers with BD or current MDD can have additional risks for adverse outcomes and may benefit from early referral for high-risk services and supportive management in pregnancy.

Indexed as

Pregnancy OutcomeAdultBirth WeightDiabetes, GestationalFemaleGestational AgeHumansInfantMaleMood DisordersOutcome Assessment, Health CarePregnancyPremature BirthYoung Adultbipolar disordergestational diabetesmajor depressionpreterm birth

Identifiers

PMID24164892
PMCPMC3999302
OpenAlexW2115242033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.