ArticleJournal of clinical periodontology2014
Improving oral implant osseointegration in a murine model via Wnt signal amplification.
Article in Journal of clinical periodontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A proof-of-concept for a novel mandibular dental implant model in mice.Clinical oral investigations · 2026Article
- Article
- Signaling pathways of dental implants' osseointegration: a narrative review on two of the most relevant; NF-κB and Wnt pathways.BDJ open · 2024Review
- Effect of systemic atorvastatin on bone regeneration in critical-sized defects in hyperlipidemia: an experimental study.International journal of implant dentistry · 2023Article
- Antineoplastic agents aggravate the damages caused by nicotine on the peri-implant bone: an in vivo histomorphometric and immunohistochemical study in rats.Clinical oral investigations · 2022Article
- Biomolecular, Histological, Clinical, and Radiological Analyses of Dental Implant Bone Sites Prepared Using Magnetic Mallet Technology: A Pilot Study in Animals.Materials (Basel, Switzerland) · 2021Article
- Pre-Clinical Models in Implant Dentistry: Past, Present, Future.Biomedicines · 2021Review
- Interspecies Comparison of Alveolar Bone Biology, Part I: Morphology and Physiology of Pristine Bone.JDR clinical and translational research · 2021Article
- [MicroRNA-29a-3p regulates osteoblast differentiation and peri-implant osseointegration in a rat model of hyperlipidemia by modulating Frizzled 4 expression].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Article
- The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway.Lasers in medical science · 2019Article
- Biomechanics of Immediate Postextraction Implant Osseointegration.Journal of dental research · 2018Article
- Biophysical regulation of osteotomy healing: An animal study.Clinical implant dentistry and related research · 2017Article
- Contribution of the PDL to Osteotomy Repair and Implant Osseointegration.Journal of dental research · 2017Article
- Effects of Condensation on Peri-implant Bone Density and Remodeling.Journal of dental research · 2017Article
- From restoration to regeneration: periodontal aging and opportunities for therapeutic intervention.Periodontology 2000 · 2016Review
- Rescuing failed oral implants via Wnt activation.Journal of clinical periodontology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimTo determine the key biological events occurring during implant failure and then we use this knowledge to develop new biology-based strategies that improve osseointegration. MATERIALS AND
methodsWild-type and Axin2(LacZ/LacZ) adult male mice underwent oral implant placement, with and without primary stability. Peri-implant tissues were evaluated using histology, alkaline phosphatase (ALP) activity, tartrate resistant acid phosphatase (TRAP) activity and TUNEL staining. In addition, mineralization sites, collagenous matrix organization and the expression of bone markers in the peri-implant tissues were assessed.
resultsMaxillary implants lacking primary stability show histological evidence of persistent fibrous encapsulation and mobility, which recapitulates the clinical problems of implant failure. Despite histological and molecular evidence of fibrous encapsulation, osteoblasts in the gap interface exhibit robust ALP activity. This mineralization activity is counteracted by osteoclast activity that resorbs any new bony matrix and consequently, the fibrous encapsulation remains. Using a genetic mouse model, we show that implants lacking primary stability undergo osseointegration, provided that Wnt signalling is amplified.
conclusionsIn a mouse model of oral implant failure caused by a lack of primary stability, we find evidence of active mineralization. This mineralization, however, is outpaced by robust bone resorption, which culminates in persistent fibrous encapsulation of the implant. Fibrous encapsulation can be prevented and osseointegration assured if Wnt signalling is elevated at the time of implant placement.
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