ReviewFEMS microbiology reviews2014
Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.
Review in FEMS microbiology reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 135 citations in OpenAlex.
- Complex multicellularity is linked with expanded specialized metabolite production in microorganisms.Nature microbiology · 2026Article
- Aromatic patch in whiB-like transcription factors facilitates primary sigma factor interaction in mycobacterium tuberculosis.Communications biology · 2026Article
- Enrichment of root-associated Streptomyces strains in response to drought is driven by diverse functional traits and does not predict beneficial effects on plant growth.PLoS biology · 2025Article
- Article
- Metabolomic analysis of the impact of MtrA on carbon metabolism inMicrobiology spectrum · 2025Article
- Taxonomic description ofMicrobiology spectrum · 2025Article
- Jurassic Osmundaceous Landscapes in Patagonia: Exploring the Concept of Ecological Stasis in the Deseado Massif, Argentina.Plants (Basel, Switzerland) · 2025Article
- Whole-genome sequencing of the Streptomyces coelicolor bldA39 mutant (J1700) reveals hundreds of previously unknown mutations.Access microbiology · 2025Article
- Tiny but mighty: Diverse functions of uORFs that regulate gene expression.Computational and structural biotechnology journal · 2024Review
- Combined transcriptomic and pangenomic analyses guide metabolic amelioration to enhance tiancimycins production.Applied microbiology and biotechnology · 2024Article
- WhiB-like proteins: Diversity of structure, function and mechanism.Biochimica et biophysica acta. Molecular cell research · 2024Review
- Synthetic Biology of Natural Products Engineering: Recent Advances Across the Discover-Design-Build-Test-Learn Cycle.ACS synthetic biology · 2024Review
- SVEN_5003 is a Major Developmental Regulator in Streptomyces venezuelae.Current microbiology · 2024Article
- Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis.Nature metabolism · 2024Article
- An overview of the two-component system GarR/GarS role on antibiotic production in Streptomyces coelicolor.Applied microbiology and biotechnology · 2024Article
- Streptomyces cynarae sp. nov., a novel actinomycete isolated from the leaves of Cynara scolymus L.Antonie van Leeuwenhoek · 2023Article
- Global Effects of the Developmental Regulator BldB in Streptomyces venezuelae.Journal of bacteriology · 2023Article
- A panoramic view of the genomic landscape of the genusMicrobial genomics · 2023Article
- Review
- The evolution of morphological development is congruent with the species phylogeny in the genusFrontiers in microbiology · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
To illuminate the evolution and mechanisms of actinobacterial complexity, we evaluate the distribution and origins of known Streptomyces developmental genes and the developmental significance of actinobacteria-specific genes. As an aid, we developed the Actinoblast database of reciprocal blastp best hits between the Streptomyces coelicolor genome and more than 100 other actinobacterial genomes (http://streptomyces.org.uk/actinoblast/). We suggest that the emergence of morphological complexity was underpinned by special features of early actinobacteria, such as polar growth and the coupled participation of regulatory Wbl proteins and the redox-protecting thiol mycothiol in transducing a transient nitric oxide signal generated during physiologically stressful growth transitions. It seems that some cell growth and division proteins of early actinobacteria have acquired greater importance for sporulation of complex actinobacteria than for mycelial growth, in which septa are infrequent and not associated with complete cell separation. The acquisition of extracellular proteins with structural roles, a highly regulated extracellular protease cascade, and additional regulatory genes allowed early actinobacterial stationary phase processes to be redeployed in the emergence of aerial hyphae from mycelial mats and in the formation of spore chains. These extracellular proteins may have contributed to speciation. Simpler members of morphologically diverse clades have lost some developmental genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.