ArticleJournal of neuroendocrinology2013
Neuromedin U partly mimics thyroid-stimulating hormone and triggers Wnt/β-catenin signalling in the photoperiodic response of F344 rats.
Article in Journal of neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Conserved communication between the pars tuberalis and mediobasal hypothalamus in the Golden hamster and Svalbard ptarmigan: a genome enabled ligand-receptor pairing analysis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- TSH promotes chemerin/CMKLR1-cAMP/ERK-DIO2 signaling in primary rat ependymal cells in vitro.Journal of molecular endocrinology · 2026Article
- Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats.Antioxidants (Basel, Switzerland) · 2024Article
- Photoperiodic Remodeling of Adiposity and Energy Metabolism in Non-Human Mammals.International journal of molecular sciences · 2023Review
- Neuromedin U-deficient rats do not lose body weight or food intake.Scientific reports · 2022Article
- The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis.Frontiers in physiology · 2022Article
- Neuromedins NMU and NMS: An Updated Overview of Their Functions.Frontiers in endocrinology · 2021Review
- Role of hypothalamic tanycytes in nutrient sensing and energy balance.The Proceedings of the Nutrition Society · 2019Review
- Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis.Frontiers in endocrinology · 2019Review
- Downregulation of Deiodinase 3 is the earliest event in photoperiodic and photorefractory activation of the gonadotropic axis in seasonal hamsters.Scientific reports · 2017Article
- Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.Oncotarget · 2017Article
- A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways.Brain, behavior, and immunity · 2017Article
- Tanycytes As Regulators of Seasonal Cycles in Neuroendocrine Function.Frontiers in neurology · 2017Review
- A neuroendocrine role for chemerin in hypothalamic remodelling and photoperiodic control of energy balance.Scientific reports · 2016Article
- Article
- Hypothalamic Wnt Signalling and its Role in Energy Balance Regulation.Journal of neuroendocrinology · 2016Review
- Photoperiodic effects on seasonal physiology, reproductive status and hypothalamic gene expression in young male F344 rats.Journal of neuroendocrinology · 2015Article
- Photoperiod regulates lean mass accretion, but not adiposity, in growing F344 rats fed a high fat diet.PloS one · 2015Article
- Thyroid hormone and seasonal rhythmicity.Frontiers in endocrinology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In seasonal animals, photoperiod exerts profound effects on physiology, such as growth, energy balance and reproduction, via changes in the neuroendocrine axes. A key element of the photoperiodic response is the thyroid hormone level in the hypothalamus, which is controlled via retrograde transport of thyroid-stimulating hormone (TSH) from the pars tuberalis of the pituitary. TSH regulates type II deiodinase (Dio2) expression, which transforms inactive thyroid hormone to its active form, via TSH receptors expressed in the ependymal cells of the hypothalamus. In the present study, we hypothesised that a second peptide hormone, neuromedin U (NMU), may play a role in the photoperiodic response alongside TSH because the gene for NMU is also expressed in a strongly photoperiod-dependent manner in the pars tuberalis and its receptor NMU2 is expressed in the ependymal layer of the third ventricle in photoperiod-sensitive F344 rats. Consistent with other studies conducted in nonseasonal mammals, we found that acute i.c.v. injections of NMU into the hypothalamus negatively regulated food intake and body weight and increased core body temperature in F344 rats. At the same time, NMU increased Dio2 mRNA expression in the ependymal region of the hypothalamus similar to the effects of TSH. These data suggest that NMU may affect acute and photoperiodically controlled energy balance through distinct pathways. We also showed that TSH inhibits the expression of type III deiodinase (Dio3) in F344 rats, a response not mimicked by NMU. Furthermore, NMU also increased the expression of genes from the Wnt/β-catenin pathway within the ependymal layer of the third ventricle. This effect was not influenced by TSH. These data indicate that, although NMU acts with some similarities to TSH, it also has completely distinct signalling functions that do not overlap. In summary, the present study of NMU signalling reveals the potential for a new player in the control of seasonal biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.