Evidence map›Paper›PMID 24163790›Full record

ArticleTaiwan journal of ophthalmology2011

Myocilin and Optineurin: Differential Characteristics and Functional Consequences.

Beatrice Y J T Yue

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Taiwan journal of ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Beatrice Y J T YueDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
University of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
BIOLOGY OF TRABECULAR MESHWORK IN HEALTH &DISEASER01EY005628 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YUE, BEATRICE Y.J.T. · 1985 to 2009
$3.4M
CONNECTIVE TISSUE AND RNA STUDIES OF DISEASED CORNEASR01EY003890 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YUE, BEATRICE Y.J.T. · 1985 to 2007
$3.0M
Cellular Processing of Optineurin, the Product of a Glaucoma GeneR01EY018828 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YUE, BEATRICE Y.J.T. · 2009 to 2012
$1.7M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY003890NEI NIH HHS R01 EY005628NEI NIH HHS R01 EY018828
6 · The paper itself

Abstract

Myocilin and optineurin are two genes linked to glaucoma, a major blinding disease characterized by progressive loss of retinal ganglion cells and their axons. This review describes the characteristics of myocilin and optineurin protein products and summarizes the consequences of ectopically expressed wild type and mutant myocilin and optineurin in trabecular meshwork and/or neuronal cells. Myocilin and optineurin exhibit differential characteristics and have divergent functional consequences. They contribute to the development of glaucoma likely via distinct mechanisms.

Indexed as

GeneGlaucomaMutationMyocilinOptineurin

Identifiers

PMID24163790
PMCPMC3806134
OpenAlexW2050634569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.