ArticleJournal of ophthalmology2013
RNA Interference Targeting Snail Inhibits the Transforming Growth Factor β 2-Induced Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells.
Article in Journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies.Biomolecules · 2024Review
- Consilience and unity in ocular anterior segment research.International journal of ophthalmology · 2024Article
- Posterior Capsule Opacification: A Review of Experimental Studies.Journal of clinical medicine · 2021Review
- Prevention of posterior capsule opacification through intracapsular hydrogen peroxide or distilled water treatment in human donor tissue.Scientific reports · 2018Article
- MicroRNA-30a Regulation of Epithelial-Mesenchymal Transition in Diabetic Cataracts Through Targeting SNAI1.Scientific reports · 2017Article
- Expressions of TGF-β2, bFGF and ICAM-1 in lens epithelial cells of complicated cataract with silicone oil tamponade.International journal of ophthalmology · 2017Article
- αB-crystallin is essential for the TGF-β2-mediated epithelial to mesenchymal transition of lens epithelial cells.The Biochemical journal · 2016Article
- Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.Experimental eye research · 2016Review
- RAC1 overexpression promotes the proliferation, migration and epithelial-mesenchymal transition of lens epithelial cells.International journal of clinical and experimental pathology · 2015Article
- HER2 mediated de novo production of TGFβ leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer.Molecular oncology · 2014Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial-msenchymal transition (EMT) contributes to posterior capsule opacification (PCO) type of cataract. Transcription factors Snail is a key trigger of EMT activated by transforming growth factor β (TGF β ). This study was done to investigate the effect of Snail targeting siRNA on TGF β 2-induced EMT in human lens epithelial cells. TGF β 2 treatment of cultured human epithelial cell line (HLEB3) upregulated the expression of Snail and the EMT relevant molecules such as vimentin and α -SMA but downregulated the expression of keratin and E-cadherin. After the stimulation of TGF β 2, the HLEB3 cells became fibroblast-like in morphology, and the junctions of cell-cell disappeared. TGF β 2 treatment also enhanced migration ability of HLEB3 cells. TGF β 2-induced Snail expression and EMT were significantly inhibited by Snail siRNA. By analyzing the response characteristics of HLEB3 in TGF β 2-induced EMT model with/without Snail-specific siRNA, we concluded that Snail is an element in the EMT of HLEB3 cells induced by TGF β 2. Snail siRNA targeting can block the induced EMT and therefore has the potential to suppress the development of PCO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.