ArticleClinical obesity2013
Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss.
Article in Clinical obesity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Testosterone supplementation and body composition: results from a meta-analysis of observational studies.Journal of endocrinological investigation · 2016Pooled it
- Symptomatic response to testosterone treatment in dieting obese men with low testosterone levels in a randomized, placebo-controlled clinical trial.International journal of obesity (2005) · 2017Trial
- Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study).Asian journal of andrologyTrial
- Testosterone in men with hypogonadism and transgender males: a systematic review comparing three different preparations.Endocrine connections · 2022Review
- Hormonal Changes in High-Level Aerobic Male Athletes during a Sports Season.International journal of environmental research and public health · 2020Article
- Obesity, Male Reproductive Function and Bariatric Surgery.Frontiers in endocrinology · 2018Review
- Testosterone deficiency in adults and corresponding treatment patterns across the globe.Translational andrology and urology · 2017Review
- Testosterone Deficiency Induces Changes of the Transcriptomes of Visceral Adipose Tissue in Miniature Pigs Fed a High-Fat and High-Cholesterol Diet.International journal of molecular sciences · 2016Article
- Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies.International journal of obesity (2005) · 2016Observational
- The practical management of testosterone deficiency in men.Nature reviews. Urology · 2015Review
- Relevance of low testosterone to non-alcoholic fatty liver disease.Cardiovascular endocrinology · 2015Article
- The complex and multifactorial relationship between testosterone deficiency (TD), obesity and vascular disease.Reviews in endocrine & metabolic disorders · 2015Review
- Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men.The aging male : the official journal of the International Society for the Study of the Aging Male · 2015Article
- Testosterone and weight loss: the evidence.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Age and sex differences in childhood and adulthood obesity association with phthalates: analyses of NHANES 2007-2010.International journal of hygiene and environmental health · 2014Article
- An update on male hypogonadism therapy.Expert opinion on pharmacotherapy · 2014Article
- Testosterone, aging and survival: biomarker or deficiency.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Patient satisfaction with testosterone replacement therapies: the reasons behind the choices.The journal of sexual medicine · 2014Article
- Effects of five-year treatment with testosterone undecanoate on metabolic and hormonal parameters in ageing men with metabolic syndrome.International journal of endocrinology · 2014Article
- Effects of long-term testosterone therapy on patients with "diabesity": results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes.International journal of endocrinology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
what is already known about this subjectHypogonadism is associated with increased fat mass and reduced muscle mass, which contributes to obesity and health risks, such as cardiovascular disease.Testosterone treatment of hypogonadal men improves muscle mass and reduces fat mass; however, many of these studies are of short duration.Thus, the long-term effects of testosterone on body anthropometry are not known. WHAT THIS STUDY ADDS: Long-term testosterone treatment of hypogonadal men, up to 5 years duration, produced marked and significant decrease in body weight, waist circumference and body mass index. Hypogonadism contributes to reduced muscle mass and increased adiposity. Testosterone treatment ameliorates loss of muscle mass and reduces fat accumulation associated with hypogonadism. In this study, we evaluated the long-term effects of normalizing testosterone (T) levels in hypogonadal men on anthropometric parameters. Open-label, single-center, cumulative, prospective registry study of 261 men (32-84 years, mean 59.5 ± 8.4 years, with T levels ≤12 nmol L
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.