ArticlePediatric cardiology2014
Serum hyaluronic acid concentration in Fontan circulation: correlation with hepatic function and portal vein hemodynamics.
Article in Pediatric cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Surgical treatment of hepatocellular carcinoma after Fontan operation: three case reports and review of the literature.Clinical journal of gastroenterology · 2023Review
- Noninvasive ultrasound technique for assessment of liver fibrosis and cardiac function in Fontan-associated liver disease: diagnosis based on elastography and hepatic vein waveform type.Journal of medical ultrasonics (2001) · 2021Article
- Forns Index is a predictor of cardiopulmonary bypass time and outcomes in Fontan conversion.Heart and vessels · 2020Article
- Risk factors and serological markers of liver cirrhosis after Fontan procedure.Heart and vessels · 2016Article
- Transvenous hepatic biopsy in stable Fontan patients undergoing cardiac catheterization.Pediatric cardiology · 2014Article
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Authors and funding
6 authors.
Funding
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Abstract
Although liver fibrosis causes significant morbidity in the late postoperative period of the Fontan procedure, the diagnostic value of hyaluronic acid (HA), a serum marker of liver fibrosis, has not been established in Fontan patients. The purpose of this study was to determine whether increased serum HA concentration in Fontan patients is associated with an increase in inspiratory-to-expiratory flow rate ratio (Qin/Qex) of the portal vein (PV), which is indicative of liver fibrosis. We retrospectively studied 28 consecutive patients with Fontan circulation who underwent cardiac catheterisation for various indications. The median age at examination was 5.5 years (range 2.2-5.6). The median HA concentration was 17.7 ng mL(-1) (range 10.0-82.1), which was used to divide our 28 patients into two groups. Patients in the high-HA group had significantly greater Qin/Qex of the PV than those in the low-HA group (1.25 ± 0.12 vs. 1.12 ± 0.11, p < 0.05). Platelet counts were significantly lower in the high-HA group (216 ± 74 vs. 294 ± 104 × 10(9) L(-1), p < 0.05). No significant difference was found in inferior vena caval pressure. In conclusion, increase of HA concentration in Fontan patients accompanies the change in PV hemodynamics peculiar to liver cirrhosis and might be an early indicator of liver fibrosis.
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