ArticleThe journal of physiological sciences : JPS2014
Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats.
Article in The journal of physiological sciences : JPS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The Association of Different Types of Intermittent Fasting with Mental Health: A Protocol for Systematic Review.International journal of preventive medicine · 2025Review
- Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression.Communications biology · 2023Article
- Fasting diets: what are the impacts on eating behaviors, sleep, mood, and well-being?Frontiers in nutrition · 2023Review
- Effects of acute kidney dysfunction on hypothalamic arginine vasopressin synthesis in transgenic rats.The journal of physiological sciences : JPS · 2019Article
- Role of the serotonergic system in urethral continence reflexes during sneezing in rats.American journal of physiology. Renal physiology · 2018Article
- Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist.The journal of physiological sciences : JPS · 2018Article
- Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HTBritish journal of pharmacology · 2017Article
- Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.Journal of genetics and genomics = Yi chuan xue bao · 2016Article
- Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling.Journal of cachexia, sarcopenia and muscle · 2015Article
- Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats.The journal of physiological sciences : JPS · 2014Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effects of serotonin (5-HT) depletion induced by peripheral injection of 5-HT synthesis inhibitor p-chlorophenylalanine (PCPA) on the expression of feeding-regulating peptides expressions by using in situ hybridization histochemistry in adult male Wistar rats. PCPA pretreatment had no significant effect on basal levels of oxytocin, corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH), pro-opiomelanocortin (POMC), cocaine and amphetamine-regulated transcript (CART), neuropeptide-Y (NPY), agouti-related protein (AgRP), melanin-concentrating hormone (MCH) or orexin in the hypothalamus. Food deprivation for 48 h caused a significant decrease in CRH, TRH, POMC, and CART, and a significant increase in NPY, AgRP and MCH. After PCPA treatment, POMC and CART did not decrease despite food deprivation. NPY was significantly increased by food deprivation with PCPA, but was attenuated compared to food deprivation without PCPA. These results suggest that the serotonergic system in the hypothalamus may be involved in the gene expression of POMC, CART, and NPY related to feeding behavior.
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