ReviewCellular and molecular life sciences : CMLS2014
The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Caffeine pollution changes anti-predator behaviour in Gammarus pulex similarly to manipulative parasites.Biology letters · 2026Article
- Caffeine Exposure Alters Neurotransmission and Stress Physiology in a Freshwater Gastropod.Toxics · 2026Article
- Grey water footprint of pharmaceuticals and personal care products discharged via urban wastewater.Scientific reports · 2026Article
- Can Cuticular Hydrocarbons Be used as Chemotaxonomic Tool for Neosilba McAlpine (Diptera: Lonchaeidae)?Journal of chemical ecology · 2026Article
- Effects of Caffeine Exposure on Behaviour, Development and Physiology of the Freshwater SnailToxics · 2025Article
- Article
- Invasive ant learning is not affected by seven potential neuroactive chemicals.Current zoology · 2024Article
- Article
- Caffeine Consumption Helps Honey Bees Fight a Bacterial Pathogen.Microbiology spectrum · 2023Article
- Dozing Off With Drosophila: The Effect of Disrupted Circadian Rhythms and Sleep Disturbance on Mortality, Mood, and Addiction.Neuroscience insights · 2023Article
- Caffeine Delays Ethanol-Induced Sedation inBiology · 2022Article
- Effect of caffeine on genes expressions of developing retinas in the chick model.Anatomy & cell biology · 2022Article
- Discovery of octopamine and tyramine in nectar and their effects on bumblebee behavior.iScience · 2022Article
- Ecdysteroid kinase-like (EcKL) paralogs confer developmental tolerance to caffeine inCurrent research in insect science · 2022Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- Article
- The Taste of Caffeine.Journal of caffeine research · 2017Review
- Caffeine promotes wakefulness via dopamine signaling in Drosophila.Scientific reports · 2016Article
- Caffeine Taste Signaling in Drosophila Larvae.Frontiers in cellular neuroscience · 2016Article
- The coffee-machine bacteriome: biodiversity and colonisation of the wasted coffee tray leach.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A number of recent studies from as diverse fields as plant-pollinator interactions, analyses of caffeine as an environmental pollutant, and the ability of caffeine to provide protection against neurodegenerative diseases have generated interest in understanding the actions of caffeine in invertebrates. This review summarizes what is currently known about the effects of caffeine on behavior and its molecular mechanisms in invertebrates. Caffeine appears to have similar effects on locomotion and sleep in both invertebrates and mammals. Furthermore, as in mammals, caffeine appears to have complex effects on learning and memory. However, the underlying mechanisms for these effects may differ between invertebrates and vertebrates. While caffeine's ability to cause release of intracellular calcium stores via ryanodine receptors and its actions as a phosphodiesterase inhibitor have been clearly established in invertebrates, its ability to interact with invertebrate adenosine receptors remains an important open question. Initial studies in insects and mollusks suggest an interaction between caffeine and the dopamine signaling pathway; more work needs to be done to understand the mechanisms by which caffeine influences signaling via biogenic amines. As of yet, little is known about whether other actions of caffeine in vertebrates, such as its effects on GABAA and glycine receptors, are conserved. Furthermore, the pharmacokinetics of caffeine remains to be elucidated. Overall behavioral responses to caffeine appear to be conserved amongst organisms; however, we are just beginning to understand the mechanisms underlying its effects across animal phyla.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.