ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
Evidence for metaplasticity in the human visual cortex.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The "Cocombola Study": A Physical Phantom Model for tDCS-Induced Electric Field Distribution.Bioengineering (Basel, Switzerland) · 2025Article
- Neuroprotection and Non-Invasive Brain Stimulation: Facts or Fiction?International journal of molecular sciences · 2022Review
- Modulating intrinsic functional connectivity with visual cortex using low-frequency repetitive transcranial magnetic stimulation.Brain and behavior · 2022Article
- Tuning brain networks: The emerging role of transcranial direct current stimulation on structural plasticity.Frontiers in cellular neuroscience · 2022Review
- Altered Visual Cortical Excitability Is Associated With Psychopathological Symptoms in Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Transcranial Magnetic Stimulation as a Tool to Investigate Motor Cortex Excitability in Sport.Brain sciences · 2021Review
- Transcranial direct current stimulation induces long-term potentiation-like plasticity in the human visual cortex.Translational psychiatry · 2021Article
- Chronic Migraine Preventive Treatment by Prefrontal-Occipital Transcranial Direct Current Stimulation (tDCS): A Proof-of-Concept Study on the Effect of Psychiatric Comorbidities.Frontiers in neurology · 2021Article
- Effect of Repetitive Passive Movement Before Motor Skill Training on Corticospinal Excitability and Motor Learning Depend on BDNF Polymorphisms.Frontiers in human neuroscience · 2021Article
- Assessing differential effects of single and accelerated low-frequency rTMS to the visual cortex on GABA and glutamate concentrations.Brain and behavior · 2020Article
- Transcutaneous Spinal Cord Stimulation Enhances Quadriceps Motor Evoked Potential in Healthy Participants: A Double-Blind Randomized Controlled Study.Journal of clinical medicine · 2020Article
- Cathodal tDCS Guided by Thermography as Adjunctive Therapy in Chronic Migraine Patients: A Sham-Controlled Pilot Study.Frontiers in neurology · 2020Article
- Controlling Brain State Prior to Stimulation of Parietal Cortex Prevents Deterioration of Sustained Attention.Cerebral cortex communications · 2020Article
- Changing Brain Networks Through Non-invasive Neuromodulation.Frontiers in human neuroscience · 2018Review
- Low-Frequency rTMS of the Primary Motor Area Does Not Modify the Response of the Cerebral Cortex to Phasic Nociceptive Stimuli.Frontiers in neuroscience · 2018Article
- Beyond Rehabilitation of Acuity, Ocular Alignment, and Binocularity in Infantile Strabismus.Frontiers in systems neuroscience · 2018Article
- Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex.Neural plasticity · 2018Article
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Astrocytes and synaptic plasticity in health and disease.Experimental brain research · 2017Review
- No Modulation of Visual Cortex Excitability by Transcranial Direct Current Stimulation.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The threshold and direction of excitability changes induced by low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) in the primary motor cortex can be effectively reverted by a preceding session of transcranial direct current stimulation (tDCS), a phenomenon referred to as "metaplasticity". Here, we used a combined tDCS-rTMS protocol and visual evoked potentials (VEPs) in healthy subjects to provide direct electrophysiological evidence for metaplasticity in the human visual cortex. Specifically, we evaluated changes in VEPs at two different contrasts (90 and 20 %) before and at different time points after the application of anodal or cathodal tDCS to occipital cortex (i.e., priming), followed by an additional conditioning with low- or high-frequency rTMS. Anodal tDCS increased the amplitude of VEPs and this effect was paradoxically reverted by applying high-frequency (5 Hz), conventionally excitatory rTMS (p < 0.0001). Similarly, cathodal tDCS led to a decrease in VEPs amplitude, which was reverted by a subsequent application of conventionally inhibitory, 1 Hz rTMS (p < 0.0001). Similar changes were observed for both the N1 and P1 component of the VEP. There were no significant changes in resting motor threshold values (p > 0.5), confirming the spatial selectivity of our conditioning protocol. Our findings show that preconditioning primary visual area excitability with tDCS can modulate the direction and strength of plasticity induced by subsequent application of 1 or 5 Hz rTMS. These data indicate the presence of mechanisms of metaplasticity that keep synaptic strengths within a functional dynamic range in the human visual cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.