ArticleHuman genetics2014
Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease.
Article in Human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01221168 (ProGene), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of Family History and Germline Genetic Risk Single Nucleotide Polymorphisms on Long-Term Outcomes of Favorable-Risk Prostate Cancer.The Journal of urology · 2024Article
- Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.European urology · 2021Article
- Inflammatory Bowel Disease and the Risk of Prostate Cancer.European urology · 2019Article
- Rare germline mutations in African American men diagnosed with early-onset prostate cancer.The Prostate · 2018Article
- Systematic identification of functionally relevant risk alleles to stratify aggressive versus indolent prostate cancer.Oncotarget · 2018Article
- Association between polymorphisms in TP53 and MDM2 genes and susceptibility to prostate cancer.Oncology letters · 2017Article
- Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.Cell systems · 2017Article
- Inherited Predisposition to Prostate Cancer: From Gene Discovery to Clinical Impact.Transactions of the American Clinical and Climatological Association · 2017Article
- The clinical phenotype of hereditary versus sporadic prostate cancer: HPC definition revisited.The Prostate · 2016Article
- The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer.The oncologist · 2016Article
- Role of Genetic Polymorphisms in the Development and Prognosis of Sporadic and Familial Prostate Cancer.PloS one · 2016Article
- PRECISION MANAGEMENT OF LOCALIZED PROSTATE CANCER.Expert review of precision medicine and drug development · 2016Article
- Article
- Known susceptibility SNPs for sporadic prostate cancer show a similar association with "hereditary" prostate cancer.The Prostate · 2015Article
- Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.Pharmacogenomics and personalized medicine · 2014Review
- Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
48 authors at 20 institutions in 8 countries.
Funding
Abstract
Previous GWAS studies have reported significant associations between various common SNPs and prostate cancer risk using cases unselected for family history. How these variants influence risk in familial prostate cancer is not well studied. Here, we analyzed 25 previously reported SNPs across 14 loci from prior prostate cancer GWAS. The International Consortium for Prostate Cancer Genetics (ICPCG) previously validated some of these using a family-based association method (FBAT). However, this approach suffered reduced power due to the conditional statistics implemented in FBAT. Here, we use a case-control design with an empirical analysis strategy to analyze the ICPCG resource for association between these 25 SNPs and familial prostate cancer risk. Fourteen sites contributed 12,506 samples (9,560 prostate cancer cases, 3,368 with aggressive disease, and 2,946 controls from 2,283 pedigrees). We performed association analysis with Genie software which accounts for relationships. We analyzed all familial prostate cancer cases and the subset of aggressive cases. For the familial prostate cancer phenotype, 20 of the 25 SNPs were at least nominally associated with prostate cancer and 16 remained significant after multiple testing correction (p ≤ 1E (-3)) occurring on chromosomal bands 6q25, 7p15, 8q24, 10q11, 11q13, 17q12, 17q24, and Xp11. For aggressive disease, 16 of the SNPs had at least nominal evidence and 8 were statistically significant including 2p15. The results indicate that the majority of common, low-risk alleles identified in GWAS studies for all prostate cancer also contribute risk for familial prostate cancer, and that some may contribute risk to aggressive disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.