ReviewJournal of muscle research and cell motility2013
Myosin phosphorylation and force potentiation in skeletal muscle: evidence from animal models.
Review in Journal of muscle research and cell motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanisms underlying performance impairments following prolonged static stretching without a comprehensive warm-up.European journal of applied physiology · 2021Pooled it
- Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Consecutive SSCs increase the SSC effect in skinned rat muscle fibres.Pflugers Archiv : European journal of physiology · 2025Article
- Competing effects of activation history on force and cytosolic CaPflugers Archiv : European journal of physiology · 2025Article
- The boost of force in unfused tetanic contractions at variable interpulse intervals in fast motor units of the rat medial gastrocnemius.Scientific reports · 2025Article
- Article
- Testing Green Tea Extract and Ammonium Salts as Stimulants of Physical Performance in a Forced Swimming Rat Experimental Model.International journal of molecular sciences · 2024Article
- Article
- Time course changes in in vivo muscle mechanical function and CaExperimental physiology · 2024Article
- Mechanism of post-tetanic depression of slow muscle fibres.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Article
- In vivo potentiation of muscle torque is enhanced in female mice through estradiol-estrogen receptor signaling.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Posttetanic potentiation improves neuromuscular efficiency of mouse muscle in vitro.Physiological reports · 2022Article
- Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro.Pflugers Archiv : European journal of physiology · 2022Article
- Beyond Nernst: the effects of extracellular potassium on post-tetanic twitch potentiation in skeletal muscle.Pflugers Archiv : European journal of physiology · 2022Article
- Time of Day and Muscle Strength: A Circadian Output?Physiology (Bethesda, Md.) · 2021Article
- The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- What are the best isometric exercises of muscle potentiation?European journal of applied physiology · 2019Article
- Post-activation Potentiation Versus Post-activation Performance Enhancement in Humans: Historical Perspective, Underlying Mechanisms, and Current Issues.Frontiers in physiology · 2019Review
- Epinephrine augments posttetanic potentiation in mouse skeletal muscle with and without myosin phosphorylation.Physiological reports · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contractile performance of mammalian fast twitch skeletal muscle is history dependent. The effect of previous or ongoing contractile activity to potentiate force, i.e. increase isometric twitch force, is a fundamental property of fast skeletal muscle. The precise manifestation of force potentiation is dependent upon a variety of factors with two general types being identified; staircase potentiation referring to the progressive increase in isometric twitch force observed during low frequency stimulation while posttetanic potentiation refers to the step-like increase in isometric twitch force observed following a brief higher frequency (i.e. tetanic) stimulation. Classic studies established that the magnitude and duration of potentiation depends on a number of factors including muscle fiber type, species, temperature, sarcomere length and stimulation paradigm. In addition to isometric twitch force, more recent work has shown that potentiation also influences dynamic (i.e. concentric and/or isotonic) force, work and power at a range of stimulus frequencies in situ or in vitro, an effect that may translate to enhanced physiological function in vivo. Early studies performed on both intact and permeabilized models established that the primary mechanism for this modulation of performance was phosphorylation of myosin, a modification that increased the Ca(2+) sensitivity of contraction. More recent work from a variety of muscle models indicates, however, the presence of a secondary mechanism for potentiation that may involve altered Ca(2+) handling. The primary purpose of this review is to highlight these recent findings relative to the physiological utility of force potentiation in vivo.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.