ArticlePflugers Archiv : European journal of physiology2014
Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane.
Article in Pflugers Archiv : European journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- ATAD-3 couples plasma membrane injury to mitochondrial CaNature communications · 2026Article
- MCU-independent CaScientific reports · 2024Article
- Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches.Cell biology and toxicology · 2023Article
- The role of extended synaptotagmin at membrane contact sites in cancer research.Frontiers in cell and developmental biology · 2023Review
- Mitochondrial calcium exchange in physiology and disease.Physiological reviews · 2022Review
- Regulation of Mitochondrial CaAnnual review of physiology · 2021Review
- MCUb Induction Protects the Heart From Postischemic Remodeling.Circulation research · 2020Article
- Article
- The debate continues - What is the role of MCU and mitochondrial calcium uptake in the heart?Journal of molecular and cellular cardiology · 2020Review
- Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria.The Journal of biological chemistry · 2018Article
- New insights into the role of mitochondrial calcium homeostasis in cell migration.Biochemical and biophysical research communications · 2018Review
- Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs.Oncotarget · 2017Article
- Direct activation of CaEuropean journal of pharmacology · 2017Article
- Intact mitochondrial CaFree radical biology & medicine · 2017Article
- Review
- UCP3 Regulates Single-Channel Activity of the Cardiac mCa1.The Journal of membrane biology · 2016Article
- The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.American journal of physiology. Cell physiology · 2016Review
- Article
- UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria.Pflugers Archiv : European journal of physiology · 2015Article
- Modulation of the matrix redox signaling by mitochondrial Ca(2.).World journal of biological chemistry · 2015Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A protein referred to as CCDC109A and then renamed to mitochondrial calcium uniporter (MCU) has recently been shown to accomplish mitochondrial Ca(2+) uptake in different cell types. In this study, we investigated whole-mitoplast inward cation currents and single Ca(2+) channel activities in mitoplasts prepared from stable MCU knockdown HeLa cells using the patch-clamp technique. In whole-mitoplast configuration, diminution of MCU considerably reduced inward Ca(2+) and Na(+) currents. This was accompanied by a decrease in occurrence of single channel activity of the intermediate conductance mitochondrial Ca(2+) current (i-MCC). However, ablation of MCU yielded a compensatory 2.3-fold elevation in the occurrence of the extra large conductance mitochondrial Ca(2+) current (xl-MCC), while the occurrence of bursting currents (b-MCC) remained unaltered. These data reveal i-MCC as MCU-dependent current while xl-MCC and b-MCC seem to be rather MCU-independent, thus, pointing to the engagement of at least two molecularly distinct mitochondrial Ca(2+) channels.
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Registered trials
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